The main goal was comparison of postoperative pain in leg fracture patients with preoperative administration of different doses of CELECOXIB. This randomized double blinded study was done on ASA I , II patients in 20 -40 candidated for leg fracture operation.inclusion criteria were: no history of opium addiction, no history of cardiac disease and previous cardiac problems (MI , CAD ), no history of CVA, no previous analgesic consumption,
exclusion criteria were : analgesic consumption prior premedication, time of surgery more than 3 h , multiple trauma and height less than 150cm. smaple size was 60 (20 in each group). they divided in 3 groups : in group 1 400 mg celecoxib administered the night before surgery.in group 2 , 200 mg the night before and 200 mg in the morning , and group 3 recieved no premedication. After intravenous infusion of 5ml/kg normal saline to all patients, spinal anesthesia done with 3 ml bupivacaine 0.5% .The time of starting and ending of the operation and anesthesia was recorded. level of anesthesia under T10 mentioned as the ending time of anesthesia and in cases with level T10 at the beginning of the operation, leve L1 considered as the end time of anesthesia. Mean of VAS and the time of first analgesic request by the patients and total opium consumption during 24h after surgery was compared between 3 groups.