The effect of hydroalcoholic extract of Nasturtium officinale on level of vitamin C and E, protein carbonyl and inflammatory markers in chronic hemodialysis patients.

Determining the effect of hydroalcoholic extract of Nasturtium officinale on the levels of vitamins C and E, carbonyl protein and inflammatory markers in patients undergoing chronic hemodialysis

A randomized controlled clinical trail with parallel, double_blind, randomized, phase 2 group on 70 patients used the random allocation rule.

Patients undergoing chronic hemodialysis referred to Shahid Beheshti Hospital in Yasuj are randomly divided into two groups by random allocation method. patients in the intervention group (35 patients) receive watercress extract capsules and in the control group (35 patients) receive placebo ( flour capsules) in the same form and amount. The treatment protocol in both groups in 500 mg capsules twice a day. Follow-up of patients is done every week during treatment and 8 weeks after the end of treatment. It should be noted that the patient and the researcher will not know about the assignment of groups and it is a double-blind study.

Inclusion criteria;18 years of age and older; Receive hemodialysis at least twice a week for about 3 months; Negative history of taking drugs that affect inflammatory markers such as corticosteroids and nonsteroidal anti inflammatory drugs (NSAIDs) in a recent month Exclusion criteria: Causes unpredictable drug side effects; Patients who refused to cooperate and continue the study and received the drug for less than 4 weeks; Development of active infectious diseases, cirrhosis and congestive heart failure and malignancy during the study and the need for kidney transplantation; Malnutrition and cachexia (body mass index less than 18 kg / m2); Albumin less than 3

Intervention group: hydroalcoholic extract of watercress Control group:Capsules containing flour

Carbonyl protein IL-6 TNF-α Vitamin E Vitamin C

In this study, we will use the Restricted randomization method of the randomization Random allocation rule method. For this purpose, first determine a total sample size, then randomly assign a set of them to the intervention group and the rest to the control group.35balls for the intervention group and 35balls for the control group are placed in a lottery container and then the balls are randomly removed from the container without replacement and the created sequence is recorded.

Capsules are individually packed envelopes and have an identification number. Capsules and envelopes of Nasturtium officinale extract and placebo are offered in exactly the same appearance and packaging, which will blind the participants and the researcher.