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The comparison of the effect of garlic allicin and vitamin C on delayed onset muscle soreness and some plasma markers in athletes

Protocol summary

Summary
The aim of this study was to investigate and compare the effect of garlic allicin and vitamin C on delayed muscle soreness, creatine kinase enzymes and lactate dehydrogenase in athletes. For this reason, 30 individuals among 72 volunteer club male karate athletes who aged between 16-18 years with healthy cardiovascular, pulmonary and renal system, also without consumption of any antioxidant supplements including vitamins C, E,… and anti-inflammation drugs, were selected randomly and were divided into 3 different groups of garlic allicin, vitamin C and placebo and consumed the supplements 14 days and 2 days pre and post- physical activity, respectively. 14 days after supplement consumption, the contestants ran on the treadmill with gradient of -5% and 75% heart rate reserve (HRR). In order to measure the variables of the study (CK and LDH), the blood samples of the contestants were collected 14 days pre and post supplement consumption and also 24, 1 and 48 hours post physical activity.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT201010245000N1
Registration date: 2011-01-30, 1389/11/10
Registration timing: retrospective

Last update:
Update count: 0
Registration date
2011-01-30, 1389/11/10
Registrant information
Name
Afsaneh Elahi
Name of organization / entity
Faculty of physical education and sport sciences, Islamic Azad University of Karaj
Country
Iran (Islamic Republic of)
Phone
+98 935 549 4101
Email address
elahi.afsaneh@yahoo.com
Recruitment status
Recruitment complete
Funding source
Personal resources/Investigator
Expected recruitment start date
2010-08-03, 1389/05/12
Expected recruitment end date
2010-09-23, 1389/07/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The comparison of the effect of garlic allicin and vitamin C on delayed onset muscle soreness and some plasma markers in athletes
Public title
Effect of garlic allicin and vitamin C on muscle soreness exercise-induced
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria: physical health. Exclusion criteria: family history of cardiovascular defects, family history of pulmonary and renal defects, antioxidant supplement consumption including vitamin C, E,.., anti-inflammation drugs consumption.
Age
From 18 years old to 26 years old
Gender
Male
Phase
3
Groups that have been masked
No information
Sample size
Target sample size: 30
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Faculty of nursing and midwifery, Islamic Azad University of Karaj
Street address
Shahid Moazen Blvd, Rajaee shahr
City
Karaj
Postal code
Approval date
2010-11-10, 1389/08/19
Ethics committee reference number
0016

Health conditions studied

1

Description of health condition studied
Delayed onset muscle soreness
ICD-10 code
M79.9
ICD-10 code description
Soft tissue disorder, unspecified

Primary outcomes

1

Description
serum creatine kinase enzyme
Timepoint
before intervention, on 14 days post intervention and before exercise, 1, 24, 48 hours after 14 days intervention and exercise
Method of measurement
blood sample

2

Description
serum lactate dehydrogenase enzyme
Timepoint
before intervention, on 14 days post intervention and before exercise, 1, 24, 48 hours after 14 days intervention and exercise
Method of measurement
blood sample

Secondary outcomes

1

Description
Rate of perceived exertion (evaluate muscle soreness)
Timepoint
before intervention, on 14 days post intervention and before exercise, 1, 24, 48 hours after 14 days intervention and exercise
Method of measurement
score of borg’s scale

Intervention groups

1

Description
vitamin C intake 1000 mg/pday for 16 days
Category
Prevention

2

Description
garlic allicin intake 70 mg/pday for 16 days
Category
Prevention

3

Description
placebo intake for 16 days
Category
Placebo

4

Description
run on downhill treadmill with the gradient of -٪5 at ٪75 of heart rate reserve (HRR) for 45 min
Category
Other

Recruitment centers

1

Recruitment center
Name of recruitment center
Faculty of physical education and sport sciences, Islamic Azad University of Karaj
Full name of responsible person
Afsaneh Elahi
Street address
Shahid Moazen Blvd, Rajaee shahr
City
Karaj

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Afsaneh Elahi (Personal resources)
Full name of responsible person
Afsaneh Elahi
Street address
Faculty of physical education and sport sciences, Islamic Azad University of Karaj, Shahid Moazen Blvd, Rajaee shahr
City
Karaj
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Afsaneh Elahi (Personal resources)
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Faculty of physical education and sport sciences, Islamic Azad University of Karaj
Full name of responsible person
Afsaneh Elahi
Position
Master of Science in physical education and sport sciences
Other areas of specialty/work
Street address
Faculty of physical education and sport sciences, Islamic Azad University of Karaj, Shahid Moazen Blvd, Rajaee shahr
City
Karaj
Postal code
Phone
+98 935 549 4101
Fax
Email
elahi.afsaneh@yahoo.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Faculty of physical education and sport sciences, Islamic Azad University of Karaj
Full name of responsible person
Afsaneh Elahi
Position
Master of Science in physical education and sport sciences
Other areas of specialty/work
Street address
Faculty of physical education and sport sciences, Islamic Azad University of Karaj, Shahid moazen Blvd, Rajaee shahr
City
Karaj
Postal code
Phone
+98 99355494101
Fax
Email
elahi.afsaneh@yahoo.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Faculty of physical education and sport sciences, Islamic Azad University of Karaj
Full name of responsible person
Afsaneh Elahi
Position
Master of Science in physical education and sport sciences
Other areas of specialty/work
Street address
Faculty of physical education and sport sciences, Islamic Azad University of Karaj, Shahid Moazen Blvd, Rajaee shahr
City
Karaj
Postal code
Phone
Fax
Email
elahi.afsaneh@yahoo.com
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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