The effects of aerobic training along with spirulina supplementation on markers of hepatic, cardiovascular, lipid profile and anthropometric indices in women with overweight and obesity

Determining of the effects of aerobic training along with spirulina supplementation on markers of hepatic, cardiovascular, lipid profile and anthropometric indices in women with overweight and obesity

Clinical trial with control group, with factorial groups, single-blind, randomized, phase 3 on 40 people. For randomization, block design is used.

Referral to a private clinic in Ramsar in 1399, selection of 40 people based on inclusion criteria, randomization into 4 groups, intervention and aerobic training for 8 weeks, completion of the individual consent, physical activity and 24-hour recall questionnaires, receiving 5 Cc of blood before and after the intervention. Blinding of statistical analyzer, coding by a third party who does not know the details.

Inclusion criteria: Willingness to participate in the study Women between 20 to 50 years old Body mass index (BMI) between 25 to 35 (kg / m2), Exclusion criteria: Use of other dietary supplements, probiotics and anti-inflammatory drugs, Use of any antioxidant supplements in the last 3 months, Use of immunosuppressive drugs, Following of special diets, Pregnancy, lactation, Smokers, Menopause, Metabolic and chronic diseases

Supplement: Three capsules 500 mg/d of spirulina, 2) Placebo: (three capsules 500 mg/d containing starch), 3) Aerobic training (three times/week, 1 hour each time) and three capsules 500 mg/d of spirulina, 4) Aerobic training (three times/week, 1 hour each time) and placebo (three capsules 500 mg/d containing starch)

Markers of hepatic, cardiovascular, lipid profile and anthropometric indices

Assignment of people in each of the study groups (supplement, placebo, aerobic training and supplement, aerobic training and placebo) will be done by "Random allocation software" using classified randomized blocking method (block size: 4). In addition, in order to reduce selection bias error, allocation concealment will be used. This will be done by assigning unit codes (two codes A and B) to each person's capsules. In this way, 60 people will be randomly allocated to supplement (n = 10), placebo (n = 10), aerobic training and supplement (10), aerobic training and placebo (n = 10) groups. In fact, each person will receive a can containing code A or B, and eventually 20 people will receive cans containing code A and 30 people will receive cans containing code B. Also, 20 people in two groups will receive aerobic training in addition to supplement or placebo.

In the present study, the statistical analyst will be blinded to the study groups. Before starting the study, the cans containing the respective capsules will be coded by a person other than the researcher (this person will not aware of the details of the research) to A and B, so that the type of received capsules in each group will be blinded for researcher. Also, placebo and supplement capsules will be similar in terms of color, shape, size and taste. In addition, cans containing the supplement and placebo will be quite similar.