Effect of combined vaginal cream (including honey, olive oil, and propolis) and oral contraceptive pill versus placebo with on treatment of functional cyst of ovary: a randomized clinical trial

To assess the effect of combined vaginal cream (including honey, olive oil, and propolis) and oral contraceptive pill versus placebo with on treatment of functional cyst of ovary

This is a randomized clinical trial, phase III, in which 60 eligible patients will be randomly assigned to the intervention and control groups.

The eligible patients with cervicitis referring to the Health Centers in Hamadan city during the study period will be enrolled in the trial and will be randomly assigned to the intervention and control groups through the block randomization.

Inclusion criteria: Age of 18 to 49 years, Functional cyst of ovary, Cyst of ovary less than 6 cm, Exclusion criteria: Pregnancy or breastfeeding, Complex raptured cyst, Taking antibiotic or immunosuppressive medications to vaginal drugs in the past 2 weeks, Abnormal uterine bleedings, Liver, renal, hematologic, or central nerves system diseases or diabetes or immunodeficiency syndrome

Intervention group 1: Combined vaginal cream (containing honey, olive, propolis) every night for 21 nights and after menstruation repeated for 21 nights Intervention group 2: Oral contraceptive pill every night for 21 nights and after menstruation repeated for 21 nights Control group: Receiving no treatment.

Primary outcome: Clinical symptoms, size of the ovarian cyst

The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare six sheets of paper, writing on two sheets the name of the intervention 1 and on two other sheets the name of the intervention 2 and on the third two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all six sheets are drawn. The six paper sheets will be then placed back into the container, and this action repeated until the sample size is reached.