The evaluation of efficacy of antibiotic lock accompanied by systemic antibiotic therapy in permanent haemodialysis by probability of catheter infection on the rate of infection of the catheter

Evaluation of the effect of using antibiotic locker simultaneously with systemic antibiotic treatment on increasing catheter retention in hemodialysis patients with the possibility of catheter infection

Randomized clinical trial, with control group, with parallel groups, one-way blind, phase 3 on 60 patients. For randomization, the blocking method was performed with sealedenvelope.com online software and the sealed envelope concealment method was performed.

Sixty patients undergoing hemodialysis suspected of catheter infection referred to Amir Al-Momenin Hospital in Arak are randomly divided into control and intervention groups.The control group received standard treatment for catheter infection and premi-cath lock was routinely performed using heparin. The intervention group received standard treatment for catheter infection and permi-cath lock was performed using a hand-made solution containing antibiotics and heparin. Blinding is one-way blind and only patients are not aware of the study groups and patients' permi-cath will be lock in both groups using a colorless solution with equal volume.

Inclusion criteria: Hemodialysis patients suspected of catheter infection, Exclusion criteria: Tunnel infection, concomitant infection, HIV positive, immunosuppression, intravenous drug addiction, severe sepsis

Group A - patients who, in addition to systemic antibiotic therapy ،vancomycin and ceftazidime; Antibiotic lock of permi-cath lumens are made according to the solution making protocol in the design method. Group B - Patients who are routinely treated with systemic antibiotics vancomycin and ceftazidime through a peripheral vein and permi-cath lumens are routinely sealed with heparin alone.

Fever, length of hospital stay, leukocytosis

Patients will be divided into two groups using block randomization method. In this way, before performing the disease, random block sequences will be created using the online software sealedenvelope.com and in 10 sequences of 6. The created sequences will then be placed in dark and sealed envelopes and the sequences will be numbered, respectively, and the disease will be treated using the created sequences, respectively.

This study was performed as a one-sided blind and the blinding will be done in such a way that the participating patients are not aware of the study groups and the type of their intervention and the participating groups are known only by letters (A and B). The clinical caregiver and the facilitator are aware of the study groups.