Comparison of the effectiveness and speed of shivering treatment after general anesthesia with pethidine and doxapram in patients undergoing orthopedic surgery and urological surgery referred to Firoozgar Hospital in Tehran.

Determining the effectiveness and speed of shivering treatment after general anesthesia with pethidine and doxapram.

This study is a double-blind, randomized, phase 3 clinical trial with control group, with parallel groups and 56 patients and uses block randomization method.

Patients seeking orthopedic or urological surgery undergo standard anesthesia. When patients regain consciousness and have chills, all non-pharmacological procedures such as warming or covering the patient with a blanket are performed. If there is no response to treatment, patients are divided into two groups. In the first group, selected patients are injected with pethidine based on their weight, and in the second group, patients are injected with doxapram based on their weight, and the findings are recorded and analyzed based on the objectives. This study is performed in Firoozgar Hospital in Tehran.

Inclusion criteria: Patients with ASA I, II anesthesia level, Patients aged 20 to 60 years undergoing orthopedic surgery and nephrology, Surgery less than 4 hours Exclusion criteria: History of lung disease, Drug allergy to pethidine or doxapram.

Group 1: Patients who have not responded to non-pharmacological treatment of shivering after surgery and will be injected with pethidine based on their weight. Group 2: Patients who have not responded to non-pharmacological treatment of shivering after surgery and will be injected with doxapram based on their weight.

Shivering after surgery, Hypoxia

In this study, we use the block randomization method so that after selecting patients according to the inclusion and exclusion criteria by selecting numbers from the table of random numbers and adapting to the blocks, patients are divided into study groups.To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC

In this study, people who are responsible for patient care and analysis of statistical data do not know about the treatment process and study groups, and information is provided to them in groups A and B.