The effect of preoperative administration of gababentin to prevent or reduce pain following laparoscopy of advanced endometriosis

The effect of Gababentin preoperative administration to prevent or reduce pain following laparoscopy of advanced endometriosis

Clinical trial with control and intervention group, three blind strains, phase 3 on 140 patients with 70 patients in each group

This study was performed in women with endometriosis referred to Hazrat Rasool Akram Hospital in 1300-1400. 70 patients with endometriosis will be in the gabapentin treatment group and 70 patients with endometriosis will be in the control group. Written consent to participate in the study is obtained. Then, in the treatment group, 600 mg of gabapentin with 30 cc of water is given one hour before the operation, and in the control group, placebo is given that have the same packaging and color. Patients All patients involved in this study, including surgeons and anesthesiologists and nurses, are not aware of the type of drug given to the patient. All patients undergo general anesthesia and laryngeal intubation. The operation time and operation technique are the same for all patients.

Inclusion criteria: All patients with endometriosis aged 16-40 years in Stage 3 and 4 diseases. Exclusion criteria: Kidney and liver patients, patients with gabapentin allergy, patients with mental disorders and epilepsy, as well as patients who have taken painkillers and any drugs and cigarettes one week before surgery

70 patients with endometriosis will be in the gabapentin treatment group and 70 patients with endometriosis will be in the control group. Then, in the treatment group, 600 mg of gabapentin with 30 cc of water is given one hour before the operation, and in the control group, placebo is given that have the same packaging and color.

Reducing pain and reducing postoperative drug use using a single dose of gabapentin before surgery

Random allocation in this study is limited to intervention and placebo groups using randomization. Random allocation law is the simplest and most limited method of randomization. This method represents a large block for the entire sample volume. For this purpose, the researchers first determined a total sample size, then randomly assigned a set of them to group A and the remainder to group B. For example in this study. A sample of 140 balls, 70 balls for intervention group A and 70 balls for intervention group B, was placed in a lottery container and then the balls were randomly removed from the container and replaced. This method is used for two or more group experiments.

This is a double-blind study. The participant, the treating physician, the data collector, and the data analyzer are blind to the type of drug (drug and placebo). Randomization will be performed using a computer program. The codes are randomly selected for each participant. Each patient has a unique code. Based on the coding on the drug, the lead researcher will provide the drug to the participant.