Investigation the effect of the 24 and 48-hour changing in chloride sodium 0.9% used in infusion of drug on the amount of phlebitis and serum infection

Determining the effect of 24 and 48 hours replacement of sodium chloride serum used in drug infusion on the rate of infection and phlebitis

Clinical trial with control group, with parallel groups, double-blind, randomized, on 300 patients. Permutation blocks were used for randomization.

Participants are selected from patients admitted to the internal medicine and surgery wards of Shirvan Hospital and are randomly assigned to the experimental and control groups. Due to the nature of the study, it is not possible to blind the participants. The researcher records the time and date of placement of the serum and catheter, and every 6 hours the site will be monitored for phlebitis. In the experimental and control groups, serum will be changed 48 and 24 hours, respectively. At the end of these times, some of the serum is sterilized and sent to a laboratory where it is cultured by a blind laboratory expert. After 48 hours, if more than fifteen colonies of microbial growth are seen in each sample, the result is positive culture and infectious serum. Blind statistics are analyzed.

Inclusion criteria: People over the age of 18, patient consent or guardian, patient cooperation, having a drug to be infused, patients who are hospitalized for at least 48 hoursNo entry conditions: Pregnant, lactating, immunocompromised patients Suffering from skin and vascular diseases Patients receiving hypertonic substances and blood and its products, TPN solution Patients with sepsis and mental disorders Receiving anticoagulants If you have a local infection at the catheter injection site

in the control group, the serum used in the infusion of drugs will be changed every 24 hours and in the intervention group every 48 hours.

Phlebitis, serum contamination

By simple random sampling method of people referring to Hashemi Rafsanjani Hospital in Shirvan who are eligible after sample selection is divided into two experimental groups (with 48-hour change of 0.9% sodium chloride serum) and the control group (with normal 24-hour change) be. In this study, individuals were assigned to two groups using permutation block method. In this method, A represents the individual receiving the intervention and B represents the individual in the control group. Considering the quadruple block; Instead of AABB code 0, give ABAB code 1, ABBA code 2, BAAB code 3, BBAA code 4 and BABA code 5. Then, using a table of random numbers, he randomly selected the starting point. Considering the order of the numbers in the table, we place the permutation corresponding to each number we encounter. So finally, by selecting the numbers from the table, how to assign a total of 300 people to the two groups will be determined

The data analyzer does not know which group the people are in. Laboratory samples are given to the laboratory expert anonymously based on numbers and he does not know if the samples are in the intervention or control group.