Induction of abortion in the first trimester by misoprostol or misoprostol with different dose of letrozol In women referring to Akbarabadi hospital in 1398-1399

Induction of abortion in the first trimester by misoprostol or misoprostol with different dose of letrozol In women referring to Akbarabadi hospital in 1398-1399

Clinical trial with control group with mosaic group, randomized. Phase 2-3, on 114 patients undergoing abortion under 12 weeks, unilateral blindness and used for randomization by randomized block method

This clinical trial study is performed in Shahid Akbarabadi Hospital in Tehran. Patients seeking medical abortion under 12 weeks are included in the study. In the first intervention group letrozole 5 mg and misoprostol 800 mg tablets three doses every three hours vaginal, in the second intervention group letrozole 10 mg and misoprostol 800 mg three doses every three hours vaginal and in the control group placebo and misoprostol 800 mg Three doses are given every three hours vaginally.

Inclusion criteria:Age older than 18 years,Gestational age based on ultrasound findings less than 12 weeks,Patient and spouse satisfaction,Lack of systemic diseases such as hypertension, kidney disease,Hemoglobin greater than or equal to 10 g / l, diastolic blood pressure less than 95 mm Hg Exclusion criteria:Having an IUD,Any allergy to letrozole or misoprostol Liver disease, kidney failure, high blood pressure and asthma,Convulsions

Letrozole 5 mg and misoprostol tablets 800 mg three doses at intervals of three hours vaginal Letrozole 10 mg and misoprostol tablets 800 mg three doses at intervals of three hours vaginal. Placebo and misoprostol tablets 800 mg three doses at intervals of three hours vagina

The interval between induction of abortion and the onset of abortion, opening of the internal cervical opening and complete abortion are evaluated in all three groups.

The patients will be randomly assigned to interventions and control groups using block randomization. For this purpose, we will prepare six sheets of paper, writing on four sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The six paper sheets will be then placed back into the container, and this action repeated until the sample size is reached.

Patients are not aware of the type of intervention, so the study is a one-way blind.

There is not a plan to make this available