Evaluation the efficacy of the probiotic (Ramnuflor and sabular) on acute diarrhea in six months to five –year- old children referred to Heshmatieh Hospital.

1.Determining the therapeutic effect of rhenofluor probiotic for acute diarrhea in children 6 months to 2 years old referred to Heshmatieh Hospital. 2.Determining the therapeutic effect of subular probiotic on acute diarrhea in children aged 2 to 5 years referred to Heshmatieh Hospital.

Clinical trial has two intervention groups and one control group. With parallel groups. Shift method sampling of 180 people sample size.

Heshmatieh Hospital. Rhenofluor probiotic for children 6 months to 2 years and subdural for 2 to 5 years.

Inclusion criteria: Children 6 months to 5 years with acute diarrhea. Exclusion criteria: 1. Clinical and laboratory symptoms based on chronic diarrhea. 2. Diarrhea lasts more than 7 days. 3. Be over 5 years old or under 6 months old. 4. The patient has a known case of immunodeficiency or cancer or a known underlying disease. 5. The patient has FTT or has a known chronic disease. 6. Weight less than 3% percentile 8. The patient has been taking probiotics for the past week. 9. Diarrhea accompanied by involvement or infection of other examined organs.

Study groups: Group 1, children 6 months to 2 years old receiving rhinofluor probiotic (n = 45) Group 2. Children 2 to 5 years old receiving subular probiotics (n = 45) Group 3, group receiving routine treatment (90 patients including 45 children 6 months to 2 years old and 45 children 2 to 5 years old)

Duration of recovery from acute diarrhea

With the easy sampling method, the qualified patients referred to Heshmatieh Hospital are randomly divided into three groups (2 intervention and control) after selecting the sample. In this study, individuals were assigned to 3 groups using permutation block method. In this method, A represents the individual receiving the first intervention, B represents the individual receiving the second intervention, and C represents the individual in the control group. After entering the study, they will enter one of the three study groups using the six-block random method. A set of different modes, BBCAAC BCAACB, CCAABB خواهد will be prepared by a statistician. Using the letters A, B and C will be considered as a symbol of one of the three intervention groups. Each of the six codes is enclosed in a sealed envelope that cannot be read from the envelope. At the patients' visit, one of the envelopes is randomly selected and the patients are assigned to one of the study groups in the order of the letters mentioned in it. Therefore, by selecting the numbers from the table, the method of assigning a total of 180 people to the three groups will be determined.

Using permutation block sampling method. Two-way blind The researcher (person implementing the project) and the people participating in the project are unaware of the type of treatment.