Efficacy of removing antibiotic therapy after appendectomy in surgical site infection in patients with imperforated appendicitis: A clinical trial

Determining the effect of eliminating antibiotic treatment after appendectomy on the prevention of surgical site infection in patients with non-perforated appendicitis

Clinical trial with intervention and control groups, parallel groups, two-way blind, randomized using random number table

Patients diagnosed with appendicitis who undergo appendectomy and are diagnosed with non-perforated appendicitis are divided into two groups. 1: They receive a dose of antibiotics before the operation and do not take any more antibiotics after the appendectomy, and instead of antibiotics, they receive a placebo. 2: Receive a preoperative dose of antibiotics and receive the same antibiotics for up to 48 hours. patients and clinicians will not know whether patients are receiving antibiotics or placebo. Patients are examined on an outpatient basis for surgical site infections, one week after surgery, 2 weeks later, and 4 weeks later.

Inclusion criteria: Patients with a diagnosis of acute appendicitis referred to Ayatollah Mousavi Medical Center in Zanjan non-admission: immunosuppression, which are: From: 1- Corticosteroids 2- Cancer 3 -Diabetes 4- leukocyte insufficiency 5 -Aids and measles 6 -Nutrition

Patients are randomly divided into two groups, one group after appendectomy did not receive antibiotics and the outcome will be measured and the outcome will be compared with the group taking antibiotics.

Purulent discharge from the wound, redness and inflammation of the wound, the presence of a mass under the skin that has purulent discharge with drainage, abdominal pain, fever

Completion of the trial

The randomization method is block randomization. The size of the blocks is 8 people. Which includes 4 people from the intervention group and 4 people from the control group. The randomization unit is individual. Randomization tool is SAS statistical software. SAS statistical software and PLAN process are used to construct random sequences. For hiding, a random sequence is created first. Then, based on the sample size of the research, a number of envelopes with aluminum wrappers (In order not to see the contents of the envelopes) are prepared. Each random sequence is recorded on a card. The cards are placed in the envelopes of the letters, respectively. In order to maintain a random sequence, envelopes are numbered on the outer surface in the same way. Finally, the envelope lids are glued and placed inside the boxes, respectively.

Patients enter the study after obtaining informed written consent. Patients and the health care provider responsible for injecting the drug do not know if the patient is receiving medication or placebo. Also, the outcome assessor does not know at any stage of the examination that the patient initially received medication or placebo.