Comparison of the effect of Salvadora persica stick (miswak) and Persica mouthwash solution on the severity of stomatitis and its pain in patients undergoing chemotherapy for Breast Cancer.

Comparison of the effect of toothbrush stick and Persica mouthwash solution on the severity of stomatitis and its pain in patients undergoing chemotherapy in breast cancer

Double-blind randomized clinical trial, phase 2 on 75 patients. A random number table will be used for randomization

75 patients with breast cancer select via convenience method and randomly assign into three groups of toothbrush stick, Persica mouthwash and control. Patients' oral health status assess before, 7 and 14 days after the start of treatment for the severity of stomatitis and pain by a trained coworker who is unaware of patients groups.

Inclusion criteria: diagnose breast cancer, The first session of chemotherapy, Age 20-60 years, Having natural teeth, no oral malformations, and oral mucousal health, Consent to participate in the study Ineligible criteria: Use of analgesics, antibiotics, and other mouthwash solutions, Drug addiction and smoking, History of sensitivity to specific substance, Underlying diseases, receiving treatment simultaneously ( radiotherapy)

Intervention group 1: Using toothbrush stick three times a day (after each meal) on the inner, outer and chewing surfaces of the teeth for 5 minutes with forward and backward movements Intervention group 2: Using soft toothbrush and toothpaste for children three times a day (after each meal) followed by using Persica mouthwash for 30-60 seconds Control group: receiving routine care in the ward

Decrease severity and pain due to stomatitis

Change and modification of the statistical community

Patients who meet the inclusion criteria will be by random allocation method and using dice (Roll of a dice),will be assigned to three groups: toothbrush stick (25 people), Persica mouthwash (25 people) and control (25 people). Numbers 1 and 2 will be considered for the toothbrush stick group, numbers 3 and 4 will be considered for the Persica mouthwash group and numbers 5 and 6 will be considered for the control group.

1. The person who evaluates the mouth of the patients participating in the study is blind. Thus, the mouth evaluation of patients in terms of incidence and severity of stomatitis will be performed by a study colleague who is unaware of the patient group, and the result is coded in the checklist of each group (patients in the Salvadora persica stick intervention group). Will register with M code and Persica mouthwash solution group with P code and control group with C code. 2. The statistical consultant in charge of data analysis will be unaware of the intervention groups; The data will be entered by the researcher with codes M, P, C in SPSS and will be provided to the statistical consultant for analysis.