Evaluation of the effect of probiotic prophylaxis in children with vesicoureteral reflux referred to the pediatric nephrology ward of Hamadan’s Besat Hospital, Iran.

The role of probiotic in the medical care of children with VUR.

All children from 2 months to 8 years old are included in the study according to the inclusion criteria. Patients who, according to the pediatric nephrologist, are candidates for medical treatment are randomly divided into two groups. The first group was treated with antibiotic prophylaxis, the second group was treated with probiotics

This one-year research will take place at Besat Hospital's nephrology clinic in Hamadan.After taking the history, physical examination, routine tests and necessary imaging examinations and grouping of patients, the protocols will be implemented.

Children aged 2 months to 8 years who have been diagnosed with VUR by a pediatric nephrologist. Exclusion criteria: Patients with obstructive causes of VUR, such as congenital obstructive uropathy and acquired obstructive causes of VUR, such as urinary stones and ureteral obstruction due to prior scarring, existence of infectious and inflammatory causes at the same time, any known immune system deficiency, whether congenital or acquired, some metabolic disorders that have been reported and parental dissatisfaction,.were excluded.

Imaging criteria (grading reflux) and nuclear scan findings are used to nominate patients for medical or surgical care. Patients that are candidates for medical attention, according to the pediatric nephrologist, are classified into two classes at randomIn the case group (intervention) prescribing probiotics as prophylaxis., Probiotics. In the control group no probiotics and prophylaxis antibiotics..

Outcome of the disease is defined as recurrence of UTI or absence of UTI and the course of the disease will be compared in terms of response to treatment and the rate of recurrence within 1 year.

Permuted block randomization method was used. Random units were children with vesicoureteral reflux. “Blockrand()” function in R statistical package was used to generate a block randomization for this clinical trial. This function will randomize subjects to the specified treatments within sequential blocks. Permuted Block Randomization (PBR) consists of 200 blocks with block length 4. Permuted Block Randomization with block length 4 is denoted by PBR(4). In each block of PBR(4) half of the patients are assigned to the treatment groups A and B, respectively. The realization of the above program is as follows: [antibiotic prophylaxis group (B) and probiotic therapy group (A)]

Control group with cephalexin capsule, which is odorless and cream-colored. The probiotic capsule treatment group is similar in structure, shape, color and odor to the control group and the drugs are indistinguishable in appearance. Due to the fact that patients are randomly assigned to groups, patients are not aware of the assigned treatment. In this study, participants enter the study based on designated blocks and without knowing the placement in groups. Patients are unaware of the placement in groups, but the facilitator (researcher) is aware of the placement and grouping.

The results of this study are published in the title of the dissertation and the subsequent paper by Hamadan University of Medical Sciences.

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Hamadan University of Medical Science

Consult the Hamadan University of Medical Sciences' Central Library.