The Effect of Fenugreek Seed Extract Supplementation on Blood glucose,Lipid profile, Appetite, Energy Intake and Macronutrient, Oxidative stress in Patients with Type 2 Diabetes:Randomized Double-blind Controlled clinical Trial

Determining the effect of fenugreek seed extract supplement on serum levels of FBS, serum insulin and IR and serum levels of TG, HDL, LDL, TC and the amount of appetite and energy and macronutrient intake and the amount of oxidant and antioxidant balance (PAB) in individuals With T2DM

This study is a randomized double-blind parallel clinical trial using the block Randomization method in which patients with type 2 diabetes will be divided into two subgroups of 23 complementary and placebo.

Patients with type 2 diabetes will be divided into two subgroups of 23 complementary and placebo using the Block Randomization method. Other than the researcher, they are coded as A and B. Patients will receive fenugreek seed extract in the form of three 335 mg tablets and the control group will receive three 335 mg placebo tablets daily for 8 weeks. Finally, the serum of the participants will be measured in terms of lipid parameters, fasting blood sugar, serum insulin and PAB.

Inclusion criteria: 1-Patients in the age range of 30-65 years 2-Having at least 6 months of diabetes history (according to criteria of American Diabetes Association) 3-BMI between 25 and 35 4-Taking blood sugar lowering drugs 5-Willingness to participate in the project Exclusion criteria: 1-Pregnancy or breastfeeding or its intention 2-Kidney, liver, gastrointestinal, thyroid, and rheumatic diseases

Individuals in the supplement group will receive three 335 mg fenugreek seed extract tablets daily and the control group will receive three 335 mg placebo tablets daily.

Fasting blood sugar, lipid profile (HDL, LDL, TG, TC), PAB (oxidant and antioxidant balance)

Subjects using RAS software (Random allocation software) and randomly, using the method of random blocking (block randomization) in terms of classification on body mass index (25-30 or 35-30 kg / m2) And gender (female or male) and inclusion in the study in the form of 4 groups and blocks with size of 6 , are divided into 2 groups of 23 people.

For double-blind research, at the beginning of the study, a set of cans containing the corresponding capsule, which are similar in appearance (color, odor, size, shape), are coded A and B by someone other than the researcher until the researcher is informed. And patients of the type of capsules received by each group.The drug and placebo were similar in characteristics and appearance (color, odor, size)