Comparison of the effect of Harpagophytum procumbens and topical Hydrocortisone in improving genital skin inflammation in patients with candidiasis

Using the most appropriate drug combination to improve genital skin inflammation in patients with candidal vaginitis by comparing the effect of harpagophytum procumbens extract and topical hydrocortisone in improving genital skin inflammation in these patients

Clinical trial with control group, with parallel groups, triple blinded, randomized, phase 3 on 60 patients

Eligible people referring to Isfahan women's clinics in the years 1400 to 1401 are divided into two groups by using random assignment software. Patients' self-report sheet of their condition based on when the patient recovers from common complaints will be filled after taking medication at home and we will recommend them to refer again after treatment. In this study, the blind groups are patient, therapist, researcher, outcome evaluator, and data analyzer. Blinding is in the form of envelopes containing random codes for patients.

Being15 to 50 years old, Being married, Examining the symptoms of acute candidate vaginitis, Not taking broad-spectrum antibiotics in the last two weeks, Not using oral and vaginal medications related to the treatment of genital infections in the last two weeks, Lack of history of allergies to the ingredients in the creams, No trichomoniasis vaginitis

Intervention is in the form of using a drug containing clotrimazole, idoquinol, aloe vera gel and Harpagophytum procumbens extract in one group and clotrimazole, idoquinol, aloe vera gel and hydrocortisone in the other group twice a day topically on the external genitalia and to It takes 7 days.

Measurement of burning, itching, inflammation and redness of the genitalia

Randomization is done with a simple random method and creating random values between zero and one in spss software. Values equal or less than 0.5 are assigned to group A and values greater than 0.5 are assigned to group B. Then, a person who was not a member of research team encodes 60 envelopes (based on the codes obtained in the randomization method) and determines the list of codes. New treatment or standard (conventional) treatment will be written in the envelope. One envelope will be given to each eligible patient according to their order of entry in the clinic to give to the specialist. The clinician will prescribe and make the necessary recommendations for each patient based on the grouping done. The researchers are blinded to patients group.

The secretary introduces the patients to the clinician based on the random allocated groups. Clinician provides treatment for each group according to their grouping. The researcher in collaboration with the clinician monitors patient’s medication use. After collecting the data of the questionnaire that was completed by the patients, the data is given to the statistical specialist for analysis. Statistical specialist is blinded to patients group.