Evaluation of the Effect of Dexmedetomidine on hemodynamics of Patients and the Mean Rate of Isoflurane Consumption in Laparoscopic Cholecystectomy surgery

The effect of dexmedetomidine on hemodynamics of patients and the average amount of isoflurane consumed by patients during laparoscopic cholecystectomy

The trial should have a control group, with parallel, double-blind, randomized, phase 3 groups performed on 80 patients. A table of random numbers is used for randomization.

This study will be performed on patients undergoing laparoscopic cholecystectomy referred to Valiasr Hospital in Arak as a randomized clinical trial with a control group. This study is a two-way blind and patients will be blind, clinical caregiver and outcome assessor compared to the study groups and blinding will be done using placebo.

Inclusion criteria: Candidate patients for laparoscopic cholecystectomy, age 18 to 65 years. Conditions of non-entry: do not undergo general anesthesia, cardiopulmonary disease, operation time more than 120 minutes

In the dexmedetomidine group, for patients, 1 μg / kg of dexmedetomidine is placed in the form of a bolus, the volume of which has reached 20cc by normal saline, during induction of anesthesia on a syringe pump. They will then receive an infusion of 0.4 micrograms per kilogram per hour of dexmedetomidine during anesthesia. In the placebo group, 20cc of normal saline is placed on the syringe pump during induction and injected for patients. We will also put the equivalent of 50cc of normal saline, which is equal to the volume of dexmedetomidine used during anesthesia in the dexmedetomidine group, on the infusion pump.

Mean isoflurane consumption, mean systolic pressure, pulse rate

Randomization in this study will be done using the random number table method. In this way,The main performer randomly selects one of the numbers in the table by determining the direction of movement and moves in the selected direction in order. Then, based on the numbers obtained, odd numbers will be assigned to group A and even numbers will be assigned to group B.

Blindness in this study will be double blind. In this way, patients are not aware of the type of drug used and the study groups, and only the main performer is aware of the type of intervention and drugs used and prepares the drugs with labels A and B. Also, the clinical caregiver and outcome assessor are not aware of the study groups and recognize the groups based on the letters A and B.