Comparison of the effect of norepinephrine and phenylephrine infusion for the prevention of hypotension during spinal anaesthesia for caesarean section

Comparison of the effect of norepinephrine and phenylephrine infusion for the prevention of hypotension during spinal anaesthesia for caesarean section.

Women undergoing cesarean section under spinal anesthesia 18 to 35 years

This double-blind clinical trial study will be performed on 100 patients undergoing cesarean section in two groups at Mousavi Hospital in Zanjan. Random allocation of samples is done by block method and using statistical software. A digital sphygmomanometer will be used to measure blood pressure and heart rate. Completion of questionnaires and recording of variables will be done by the research team during the operation and at specified times.

Entry requirements: Patients who are candidates for elective cesarean section, full-term pregnancy (37 full weeks) and singleton, patients with American Society of Anesthesiologists (ASA) 1 and 2, no underlying diseases, no drug and alcohol abuse Exit conditions: Congenital malformations of the infant, patients who have had a previous cesarean section performed midline, patients who, for whatever reason, the time between spinal anesthesia and the discharge of the baby is longer than usual ( 20 Minutes), patients who have failed during spinal anesthesia

Intervention group: Pregnant women with term pregnancies and aged 18 to 35 years who receive norepinephrine infusion (4µ g / min) immediately after spinal anesthesia until the end of cesarean section Control group: Pregnant women with term gestation and aged 18 to 35 years who receive phenylephrine infusion (4 mg / min) immediately after spinal anesthesia until the end of cesarean section

Systolic blood pressure; Diastolic blood pressure; Moderate blood pressure; heart ; Arterial umbilical cord blood gases

In this study, the restricted randomization method we use the block randomization type. Blocking is used to balance the number of samples assigned to each of the study groups. This feature helps the researcher to equate the number of samples assigned to each of the study groups whenever intermediate analyzes are needed during sampling. The size of all the blocks is equal and in this two-group experiment we will have 6 blocks (including 3 people in the intervention group and 3 people in the control group).software allocation Random is used for randomization. In addition to simple randomization, these softwares are able to generate random sequence by blocking method. For concealment, we use concealment allocation, which is the method used to execute a random sequence on the study participants, so that the assigned group is not known before the individual is assigned. Using opaque envelopes with random sequences (envelopes opaque, sealed, numbered sequentially), each of the random sequences created is written on a card and the cards are placed inside the envelopes in order.In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the lids of the letter envelopes are glued and placed in a box, respectively. At the time of arrival of eligible pregnant mothers, according to the order of inclusion in the study, one of the envelopes is opened and the assigned group of the pregnant mother is revealed.

The drug will be inserted anonymously into the infusion syringe

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