Comparative study of the effect of using silver nanoparticles dressings and alcoholic chlorhexidine impregnated dressings and conventional dressings on the rate of infection of temporary hemodialysis catheters in hemodialysis patients

Determining the effect and comparison of the use of nanosilver dressings and alcoholic chlorhexidine impregnated dressings and conventional dressings on the infection rate of temporary hemodialysis catheters in patients referred to the Educational-therapeutic hemodialysis centers of Urmia in 2021-2022

The clinical trial consists of a control group with randomized parallel groups without blinding, which will be performed on a total of 120 people in three groups of 40 people and the results of the interventions will be analyzed with SPSS 16

The sample size for the above study is 120 hemodialysis patients with a temporary catheter with a negative skin culture test. Our study has three groups of control (common dressing) (n=40), dressing with alcoholic chlorhexidine (n=40) and nanosilver dressing (n=40). 120 patients will be selected according to the inclusion criteria and skin culture will be obtained and covered with the desired dressing. After determining the answer of skin culture, patients with negative culture will be retained and will be dressed two more times and people with positive skin culture will be dressed. They will be removed from the study and replaced with another negative skin culture. Up to 120 people to be completed in the study.

Inclusion criteria: Patients with renal insufficiency with temporary temporal and subclavian catheters Exclusion criteria: Existence of infectious disease

In one group, a nanosilver dressing will be used for the hemodialysis catheter place. In the other group, an alcoholic chlorhexidine will be used for the dressing, and in the third group, the usual dressing, (povidone iodine), will be used.

Evaluation of temporary catheter infection rate in three dressing methods

Patients will be divided into three groups using a simple randomization method based on a table of random numbers. According to the sample size (120 patients), patients will first be given a code from 1 to 120 (given that the number of patients is three digits). Therefore, the given codes will be three digits: 001, 002, ......, 120) Then a number will be randomly selected from the table and we will go from top to bottom in a column in the table until the sample size is examined. To be completed. In this case, patients between 001 and 040 will be in group one, 041 to 080 in group 2 and 081 to 120 in group 3.

Blinding in this study will be done in several steps as follows 1- Preparing 120 dressing packages that are the same in terms of appearance, type of packaging and color. 2- Using a table of random numbers to assign dressing packages to three treatment groups at random. 3- After assigning the dressings to three groups, we mark them with a label of 1 to 120. 4- The researcher delivers the dressing packages to the therapist and the therapist gives the patients from 1 to 120, respectively (only the researcher is aware of the number of dressings and which treatment group each dressing package belongs to, and therefore is blind. The study is valid because the therapist and patient are unaware of the nature of the treatment and dressing).

Unidentifiable data of individuals and related information available to others Researchers will be placed. Study protocol, data analysis program and Etc. will also be shared

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Refer to this mail: pourmehr.omid@umsu.ac.ir Omid Pourmehr

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