Effect of Angiotensin-converting enzyme and β-blockers on the prognosis of patients with severely isolated brain trauma

prognosis of severe isolated brain trauma

Random function of Excel software based on patient file number will be used for randomization. Patients with severe brain trauma were included in the Excel program based on the file number and were divided into-2 groups case, control and control group based on the random button. There were three groups of 32 people in total. By entering the file number in Excel program, then the random number is selected from the data analysis command. This study has three groups that can be numbered from 1 to 3, respectively. It is clear that the repetition of each number occurs once in each group, so select the repeating each number option and select 32 for repeating the sequence. In this way, 96 units will be produced.

This study is a double-blind clinical trial, participants and researchers are not aware of the patient and drug groups.As the clinical caregiver administers the medication to the patient and the patient is unaware of the medication received.

Inclusion criteria: Severe trauma, Age greater than or equal to 18 years, No previous use of beta-blockers at home, Informed consent of the patient's guardian, Satisfaction for the patient to enter the study Exclusion criteria: Death of the patient, Do not take other drugs that affect the sympathetic system, Renal artery stenosis, Chronic kidney disease, History of drug allergy, Hyperkalemia, High creatinine, Bradycardia

Intervention group 1: Propranolol From Abidi Pharmacy :1 mg, injectable, in the first 24 hours up to two weeks Intervention group 2: Enalapril From Abidi Pharmacy:2.5 mg, gavage, in the first 24 hours after admission up to two weeks Control group: routine care

Glasgow Outcome Scale to measure level of consciousness

This study is a double-blind clinical trial in which patients are randomly divided into three groups. Random function of Excel software based on patient file number will be used for randomization. Patients with severe trauma enter the Excel program based on the file number and were divided into - 2 groups case, and control group based on the random button. There were three groups of 32 people in total. By entering the file number in Excel program, then the random number is selected from the data analysis command. This study has three groups that can be numbered from 1 to 3, respectively. It is clear that the repetition of each number occurs once in each group, so select the repeating each number option and select 32 for repeating the sequence. In this way, 96 units will be produced.

This study is a double-blind clinical trial in which patients are randomly divided into three groups. In this study, participants and researchers are not aware of which group the patient is in and which medication he is taking. As the clinical caregiver will take the medicine and the patient does not know what medicine he is taking.