Comparison of changes in inflammatory factors in patients with intertrochanteric femoral fracture treated with Dynamic Hip Screw surgery with intramedullary nailing

The aim of study was to evaluate inflammatory factors in patients with intertrochanteric femoral fracture treated with dynamic hip screw surgery with intramedullary nailing.

The design of study is a parallel that will be performed with the structure of a three phase clinical trial. In this study, 180 patients will be assigned to surgical groups by dynamic hip screw and intramedullary nailing methods by block randomization. There is no blinding in this study because patients, surgeons, and study outcome assessors are aware of the type of study groups. Randomization will be done using Random Allocation software the blocks will be identified randomly and the groups with the letters A and B.

This study was designed to evaluate inflammatory factors in patients undergoing orthopedic surgery due to intertrochanteric femoral fracture. Patients will be selected by considering the inclusion and non-inclusion criteria from the orthopedic ward of Moheb and Rasoul Akram hospitals in Tehran. Then, by block randomization method, we will assign 180 patients to groups with dynamic hip screw and intramedullary nailing surgery.

The criteria considered for the study were confirmed intertrochanteric femoral fracture and age over 18 years. If there are other fractures, the person will not be included in the study.

Patients in the intervention group will be operated using dynamic hip screw method and patients in the control group will be operated using intramedullary nailing method.

C-Reactive Protein; Interleukin 6; Tumor Necrosis Factor alpha

After selecting the participants in the study using inclusion and non-inclusion criteria, to prevent the occurrence of bias in the selection of participants to intervention and control groups, we will use the randomization method to minimize the opinion of researchers in selecting participant to study groups. The block randomization method was used in this study. The size of the blocks is considered to be four and will be selected randomly so that it is not predictable to the participants based on the blocks. First, we will receive using Random Allocation software and by determining the sample size, the number of groups, the type of randomization and is random the order of the blocks in the software output and will be shown in the software output of groups with letters A and B. Then, after selecting each patient based on the inclusion and non-inclusion criteria, the project manager will be informed and he will tell the type of intervention of that patient based on the order of inclusion of patients and compliance with the number mentioned in the randomization output.