Comparsion of intraincisional bupivacaine, tramadol and bupivacaine plus tramadol in postoperative pain in elective cesarean section patients

Comparison of the effect of postoperative pain control and complications of bupivacaine, tramadol and a mixture of bupivacaine and tramadol by injection at the incision site in patients undergoing elective cesarean section

A clinical trial with a control group, with parallel groups, double-blind, randomized, phase 3 on 90 patients by permutation block method was used for randomization by random allocation method.

Participants in the study (n = 90) will be assigned to 3 groups A, B and C by permutation block method. Patients and evaluators do not know the type of treatment groups of participating patients. Place of study: Imam Khomeini Hospital Anesthesia group

Inclusion criteria: age between 15-45 years, having informed written consent to cooperate with the study, patient classification in ASA1-2 class. Exclusion criteria: Refusal to continue cooperation in this study, adequate spinal anesthesia and its conversion to general anesthesia, allergy to any of the drugs used, history of addiction, underlying pain such as back pain, headache, history of psychiatric drugs, receiving Preoperative housing, history of addiction

Group A, which is the control group, receives 10 mg of bupivacaine, which has reached a volume of 10 ml with normal saline, which is injected by the surgeon at the incision site at the end of the operation. Group B, which is the intervention group, receives 100 mg of tramadol, which has reached a volume of 10 ml with normal saline, and is finally injected by the surgeon at the incision site. Group C, which is the intervention group, receives 10 mg of bupivacaine and 100 mg of tramadol, which has reached a volume of 10 ml with normal saline, is finally injected by the surgeon at the incision site.

The degree of pain, itching. nausea and vomiting

Patients will be assigned to three groups through random blocking. A, B and C are 15 blocks of six randomly assigned blocking process and Random Allocation software is used. All 3 drugs are similar in appearance and volume and are responsible for preparing the mentioned drugs. Fill in syringes A, B and C and the anesthesia assistant injects the medicine into the patient according to the randomization block and random letters A, B and C without knowing the type of medicine. It is prepared in another room and delivered to the injector in the operating room.

The drugs are prepared in a similar appearance and volume in another room and delivered to the injector in the operating room, where the patient injector and the evaluator are kept blind according to the type of treatment groups of the patients.