Comparison of the effect of Saccharomyces Cerevisiae enriched with selenium and mineral selenium on postpartum depression and sexual satisfaction:A triple-blind randomized controlled trial

Comparison of the effect of Saccharomyces Cerevisiae enriched with selenium and mineral selenium on postpartum depression and sexual satisfaction

The present study is a controlled trial, phase 3, with three parallel groups, triple blind, which will be performed on 108 people in three groups. The research environment will be the health centers of Tabriz city.

This study will be performed in health centers in Tabriz. A member of the non-research team involved in the selection of samples will determine the random allocation sequence using a computer program. Closed opaque envelopes will be used numbered in order to conceal the allocation. Eligible individuals will be randomly assigned to three groups using block sizes of 3 and 6 blocks.

Inclusion criteria: Women 18 years and older, Recent low-risk pregnancies, Having a care record at the nearest health center Exclusion criteria: Existence of prenatal depression, A score above 23 on the Edinburgh Questionnaire, History of depression or any other mental disorder, Death or hospitalization of the baby in the intensive care unit, Stillbirth, Hospitalization of the mother due to postpartum complications, Having chronic diseases such as liver and kidney disease, Having frequent miscarriages and having a history of infertility, Having a history of a child with a mental or physical disability, Allergy to fungi and yeast

In this study, two groups will receive mineral selenium and Saccharomyces Cerevisiae enriched with selenium as the intervention groups and the third group will receive placebo as the control group.

Score of depressive symptoms before and after the intervention, Score of sexual satisfaction before and after the intervention.

Breastfeeding women with mild to moderate depression scores using a randomized blocking method with a size of three or six blocks using RAS (Random Allocation Software) with a 1: 1: 1 allocation ratio in The three groups receiving Saccharomyces cerevisiae enriched with selenium, mineral selenium and placebo will be included. To hide the allocation, the group name will be placed inside a numbered consecutive matte envelope. Envelope preparation and random allocation sequencing will be performed by the non-research person.

The drugs and their placebo will be prepared by the pharmaceutical company in a completely similar way in terms of shape, color and smell. The researcher, participants, data analyst, and outcome reviewer are unaware of the type of intervention received.