Comparison of the effectiveness of two different doses of Dexmedetomidine on the prevention of nausea and vomiting in Discectomy under spinal anesthesia

Determination of the effect of two doses of dexmedetomidine on the prevention of nausea and vomiting in discectomy under spinal anesthesia

Clinical trial with control group, with parallel groups, double-blind, randomized, phase 2 on 135 patients. Randomization was performed by individual block method using a table of random numbers.

This is a double-blind clinical trial that was performed on 135 patients undergoing spinal anesthesia Discectomy in Al-Zahra Hospital in Isfahan in 1398-99. After the approval of the university ethics committee and obtaining the patients' consent, the patients entered the groups by block random allocation. In each group, after spinal anesthesia, the desired intervention was applied and the patient's vital signs were measured and recorded. The clinical caregiver was different from the person injecting the drug and was unaware of the type of intervention being performed. The surgeon and the patient were also unaware of the intervention and were therefore blind.

Inclusion criteria: Patients 18 to 60 years old who are candidates for Discectomy under spinal anesthesia with ASA class 1 and 2. Exclusion criteria: history of cardiovascular disease, fever, obesity, pregnancy, Allergy to Dexmedetomidine , drug interaction with Dexmedetomidine

Intervention group D1: 0.2 Micrograms per kilogram of body weight per hour of Dexmedetomidine brought to 10 cc by normal saline Intervention group D2: Dose of 0.5 Micrograms per kilogram of body weight per hour of Dexmedetomidine brought to 10 cc by normal saline Control group C: amount of 10 ml of normal saline, After spinal anesthesia and placing the patient in the desired position, it was received as an intravenous infusion pump for 10 minutes.

Nausea and vomiting due to dexmedetomidine injection

This is a simple randomized clinical trial in which individuals enter study groups by lottery; The drugs and placebo are placed in the desired number in sealed opaque and uniform sealed envelopes. Each of the codes is also written on a piece of paper, folded and placed inside a box. After entering the operating room, each patient takes one of the papers out of the box. Which is applied to the patient. This continues until the end of the paperwork so that the number of patients in the desired volume in the groups.

This was a double-blind controlled clinical trial in which the patient and the evaluator had no known information about the type and dose of the drug.