Effect of Propofol, Ketamin and combination of Propofol and Ketamine in prevention of coughing and laryngospasm in patients awakening from general anesthesia

The aim of present study was to compared the effect of small doses of propofol, ketamine and their combination on presence and severity of coughing and laryngospasm. It is a double blinded clinical traial. Inclusion criteria: ASA class I or II, aged between 7 to 75 years old. Exclusion: bronchial asthma, allergic disorders, upper respiratory infection symptom during the surgery, smoking, medication with ACE inhibitors ,allergic reaction to administered drugs and changing the anesthesia technique. Study population: patients who were scheduled to undergo operations under general anesthesia . Sample size:160 patients. Routine anesthesia was performed. Patient was set at one of the following groups randomly: propofol group (received propofol 0.25 mg/kg), Ketamine (received ketamine 0.25 mg/kg), combination (with the same doses) and control group (received saline 0.1 ml/kg). . when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened his eyes or made purposeful movements drugs were injwcted.Occurrence and severity of laryngospasm and coughing within 2 minutes after extubation were recorded.then presence and severity of coughing and laryngospasm were recordr in 2 min after extubation. Grading of laryngospasm 0: no symptoms; 1: stridor; 2: total occlusion of the cords (respiratory efforts with no air movement); 3: cyanosis with evidence for airway obstruction at the level of vocal cords. Grading of coughing : 0: no incidence of coughing 1: only one cough 2: two coughs to slight coughing 3: severe or repetitive coughing was Frequency and severity of coughing and laryngospasm was compared between groups.

Isfahan University of Medical Sciences