The effect of vitamin D supplementation on clinical symptoms and serum levels of some inflammatory factors in men with chronic nonbacterial prostatitis

Determining the effect of vitamin D supplementation on clinical symptoms and serum levels of some inflammatory factors in men with chronic non-bacterial prostatitis

Double-blind randomized clinical trial with control group, with parallel groups, phase 3 on 48 patients, block randomization method and allocation concealment method

A double-blind randomized controlled clinical trial, Sample includes people referring to the urology clinic of Imam Khomeini Hospital in Ahvaz with chronic pelvic pain syndrome. Patients, the clinical caregiver, and the evaluator of treatment outcomes are kept unaware of the type of treatment assigned to patients

Inclusion criteria : Men in their 20s and 50s with symptoms of chronic non-bacterial prostatitis (CPPS) Criteria for non-entry: Alcohol consumption, following special diets, regular use of antioxidant supplements over the past 6 months and other diseases, history of surgery in the last 3 years, urethral stricture, fever and chills

Intervention group: 24 people receiving vitamin D 1000 international units (25 micrograms) per day for 8 weeks Control group: 24 people receiving 25 micrograms of starch daily (placebo) for 8 weeks

Clinical signs, PSA, IL1 β

Sampling will be done by simple non-probability method, so that from the beginning of the study, all patients who meet the inclusion criteria will be selected as a sample and this will continue until the final sample size. allocation of patients to each of the study groups will be accomplished with the block random method and using sextet blocks

To reduce the possibility of information bias, the double-blind method is used; In this way, both the patients and the researcher and the person evaluating the results of the treatment will be kept unaware of the type of treatment assigned to the people. Also, in order to reduce the possibility of selection bias, after randomization, the Allocation Concealment method or the use of unit codes is used. In this way, all containers containing supplements and placebos, which are quite similar in appearance, are coded as A and B by someone outside the study, and the code can be broken only by the person who did the numbering.