Since fatigue factors in female athletes increase rapidly, it is necessary to reduce these factors with appropriate methods. Due to the fact that the production of beta-alanine (BA) in the human body is limited and less in women than men, and the response to it is higher in trained people than in untrained people.
Beta-alanine (BA) supplement, an ergogenic supplement and carnosine precursor, has been suggested to reduce or delay muscle fatigue and improve function. Beta-alanine (BA) can increase the level of muscle carnosine concentration and increases the buffering role in intense and short-term anaerobic exercise.
Design
The statistical population of this study consisted of 20-30-year-old girls who had done regular exercise at least 3 times a week for the past year. Then, 10 qualified people who meet the inclusion criteria will be selected as a sample. Subjects will be coded and divided into two groups of supplement and placebo based on random sampling by Excel software. One week after the implementation of the research protocol, the groups will change in terms of supplements and placebo and will implement the test protocol again.
Settings and conduct
The subjects will refer to the Faculty of Physical Education laboratory of Guilan University in 3 sessions. In the first session, tests related to physical fitness will be measured. In the second session, which will be held 5 days after the first session, they will be present in the laboratory at 8 in the morning and perform the protocol after warming up. Subjects will perform MVC tests for 3 seconds.
Participants/Inclusion and exclusion criteria
No musculoskeletal damage and physical problems affecting the research results
Intervention groups
Beta-alanine supplementation group; without supplement or placebo group
Main outcome variables
Maximum voluntary contraction
muscle power
rate of perceived exertion
rate of pain
General information
Reason for update
Acronym
IRCT registration information
IRCT registration number:IRCT20190720044283N2
Registration date:2021-09-01, 1400/06/10
Registration timing:retrospective
Last update:2021-09-01, 1400/06/10
Update count:0
Registration date
2021-09-01, 1400/06/10
Registrant information
Name
Siamand Abdollahpour
Name of organization / entity
Guilan university of medical sciences
Country
Iran (Islamic Republic of)
Phone
+98 13 3369 0274
Email address
siamand.abp1@gmail.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2021-08-23, 1400/06/01
Expected recruitment end date
2021-08-27, 1400/06/05
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effects of Acute β-Alanine supplementation on anaerobic performance and muscle fatigue in athletic female
Public title
Acute effect of beta-alanine supplementation on anaerobic function and muscle fatigue in female athletes
Purpose
Other
Inclusion/Exclusion criteria
Inclusion criteria:
Trained girls have had at least 3 regular workout sessions a week in the past year
No musculoskeletal injuries and physical problems
Exclusion criteria:
Existence of musculoskeletal injury and taking medication or supplements
Physician not confirming physical health
Alcohol or tobacco consumption
Age
From 20 years old to 30 years old
Gender
Female
Phase
1-2
Groups that have been masked
Participant
Care provider
Investigator
Outcome assessor
Data analyser
Sample size
Target sample size:
10
Randomization (investigator's opinion)
Randomized
Randomization description
Using the random selection method by Excel software by writing the names of the subjects in cells and then in the other part, we specify the position of the desired groups in two separate sections of 5 subjects. Then in these two sections, we will execute the following code so that they are randomly placed in groups of 5 subjects.
=INDEX($A$3:$A$12,RANDBETWEEN(1,ROWS($A$3:$A$12)),1)
Blinding (investigator's opinion)
Double blinded
Blinding description
In this study, one group will take 6 grams of beta-alanine supplement in capsules and the other group will take a placebo containing sucrose. It should be noted that capsules containing supplements or placebos will be coded by a third party who has no conflict of interest in the present study and is present merely as an observer and will distribute it with the knowledge of each individual supplement.
Placebo
Used
Assignment
Crossover
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Research Ethics Committee of Sports Science Institute (SSRI)
Street address
Fifth Alley, Mir Emad St., Ostad Motahhari St.
City
Tehran
Province
Tehran
Postal code
1587958711
Approval date
2021-07-20, 1400/04/29
Ethics committee reference number
IR.SSRC.REC.1400.079
Health conditions studied
1
Description of health condition studied
Prevent depletion of energy resources during physical activity, Reduce or delay muscle fatigue and improve performance, Increase anaerobic power
ICD-10 code
ICD-10 code description
Primary outcomes
1
Description
Electromyographic (EMG) indices of the quadriceps muscle
Timepoint
Implement the protocol in two steps with a one week wash-out interval and before and after supplementation
Method of measurement
Electromyography device (Muscle Tester ME 3000P8 Mega Electronic Ltd, Finland) with sampling frequency HZ 2000 and bandwidth Hz / 3 Db 450-30
2
Description
Maximal Voluntary Contraction (MVC)
Timepoint
Before and after supplementation
Method of measurement
Manual Muscle Testing Device (MMT, North coast, USA)
3
Description
Rate of Perceived Exertion (RPE)
Timepoint
Immediately after the fatigue protocol (consecutive side jump)
Method of measurement
Borg scale (6-20)
4
Description
Muscle Pain
Timepoint
Immediately, 24 and 48 hours after the fatigue protocol
Method of measurement
Visual Analogue Scale (VAS)
5
Description
Muscle Power
Timepoint
Before and after supplementation and Immediately after the fatigue protocol
Method of measurement
Johnson's and Bahamonde Method
6
Description
Sense of Fatigue
Timepoint
Immediately, 24 and 48 hours after the fatigue protocol
Method of measurement
Sense of Fatigue Questionnaire
Secondary outcomes
empty
Intervention groups
1
Description
Intervention group: Beta-alanine supplementation; The intervention group took 4.5 g of beta-alanine in capsules and the other group took a placebo containing the same amount of sucrose as beta-alanine. One week after the effects of the supplement disappear, in the third session, the two groups of subjects will change in terms of supplementation, and the group that uses the beta-alanine will use a placebo.
Category
Other
2
Description
Control group: The placebo group consumes 4.5 grams of sucrose in capsules. After one week, in the third session, the two groups of subjects will change in terms of supplementation, and the group that uses the placebo will use beta-alanine.
Category
Placebo
Recruitment centers
1
Recruitment center
Name of recruitment center
Faculty of Physical Education and Sports Sciences
Full name of responsible person
Dr. Javad Mehrabani
Street address
5th Kilometer of Persian Gulf Highway, Rasht, Guilan Province, Iran
City
Rasht
Province
Guilan
Postal code
4199613776
Phone
+98 13 3366 9027
Email
int@guilan.ac.ir
Web page address
https://fe.guilan.ac.ir/
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
University of Guilan
Full name of responsible person
Seyed Ziaaldein MirHossini
Street address
Rasht, km 6, Rasht-Qazvin road, Guilan University complex, in front of the central university organization, Vice Chancellor for Research and Technology