Comparison of the effects of Naproxen, Diclofenac and Piroxicam on TMD

We aimed to compare the effect of three NSAID drugs (naproxen, diclofenac and piroxicam) on temporo-mandibular disorders (TMD).

This randomized, triple-blind, clinical trial, was done on 104 patients aged 20-45 years with TMD. Patients were divided randomly (using the table of random numbers) to four groups to treat through Naproxen tablet, tablet of Diclofenac, Piroxicam capsule and Placebo.

The study was performed on 104 patients in the age range of 20 to 45 years old, who had referred to Kerman Dental School in a triple-blind randomized clinical trial. Patients were randomly divided into four groups for treatment with naproxen , diclofenac , piroxicam and placebo. Patients were unaware of the medication they were receiving. Pain was measured using the VAS index, clicking with a stethoscope, mouth opening with a cloth ruler, and sensitivity to touch. The person who evaluated the patient in the examination sessions as well as the person who analyzed the data; They did not know which treatment group the patient was in.

Pain in masticatory muscles; limitation in mouth opening; clicking sound; TMJ touch sensivity; no systemic disease; no previous supportive treatments

The study was performed on 104 patients and patients were divided into four groups: medication in the first group with Naproxen tablets at a dose of 500 mg, in the second group with Diclofenac tablets at a dose of 50 mg, in the third group with Piroxicam capsules at a dose of 10 mg Warm and in the fourth group was done with placebo for 10 days. In five stages, patients were evaluated for pain, click, tenderness and mouth opening which lasted six weeks.

Pain; clicking; AROM (Active Rate of Motion) and tenderness

104 patients randomly divided to 4 groups using random number table. A set of numbers without a specific pattern or order were generated in a completely random manner and became a table. In order to use the table of random numbers, the researcher first determined the table to read the numbers from above. Numbers 26-01 for prescription of naproxen, 27-52 for diclofenac, 78-53 for piroxicam and 104-79 for Placebo were also considered. The researcher then touched one of the numbers and moved in one of the predetermined directions, recording the numbers and assigning them to different groups.

Three groups were blind: 1. Patients about their drugs 2. A dentist who examined the patients in periodic meetings (care provider) 3. Data analyser