Comparison of the effect of Apotel and Magnesium Sulfate analgesics on pain and Pethidine dose after Maxillofacial surgery.

Comparing the effect of Apotel and Magnesium Sulfate on pain and Pethidine consumption in patients with Maxillofacial surgery.

Phase 2-3 double-blind randomized prospective clinical trial with using Randomize on 60 patients.

It will be examined in Bu Ali Hospital in 1400. Researchers and patients are considered blind. One hour before the end of surgery in group A, Apotel is infused within 20 minutes. In group B, 50 kg / mg of magnesium sulfate is infused. Before discharge from the recovery, you will be asked about the pain and its severity based on Visual Analogue Scale (VAS), and in the relevant section, you will be asked every 4 hours for the next 12 hours. It is prescribed at a dose of 30 mg. The total dose of Pethidine is recorded postoperatively, and individuals who received Pethidine at any time during the 12-hour study were excluded from comparing the pain between the two study groups and will be compared separately.

Admission: Absence of severe drug sensitivities; Men and Women 45-18 years; ASA class I and II anesthesia; Informed to study; Candidates for Maxillofacial surgery; Reoperatio or Emergency or Multiple Trauma Not dependent on drugs; Alcohol or Psychedelics. Absence: Serious cardiac arrhythmia and severe arrhythmia; Chronic treatment with Corticosteroids or Calcium channel blockers or NSAIDs; Severe Liver and Kidney diseases, severe anemia.

Apotel injection to evaluate its analgesic effect on patients with maxillofacial surgery. Injection of Magnesium Sulfate to evaluate its analgesic effect on patients with maxillofacial surgery.

Postoperative pain after injection of Apotel and Magnesium Sulfate after surgery, Dosage of pethidine after injection of opotel and magnesium sulfate after surgery

A prospective, randomized, double-blind, single type and individual clinical trial using sealed envelopes. The total number of drugs (30 Apoteles and 30 Magnesium Sulfate) is sealed in white bags and then randomly placed from 1 to 60 pieces. We do not know what medicine is in which package. Numbers 1 to 60 are written on the cards. The patient selects the card. The anesthesiologist reads the number on the card and select the envelope which has the number on the card, opens the envelope during the surgery and is informed of the type of medicine, writes the number on the patient's form, and writes the code and type of medicine in the patient's file. The file is archived in the surgery department so that the researcher enters the type of medicine at the end of the sampling by referring to the file. In this way, we will have two groups of 30 people that were randomly divided.

Drugs are sealed in coded envelopes and delivered to the anesthesiologist. In any surgery, the anesthesiologist and surgeon are aware of the type of medication. The anesthesiologist records the code in the patient file. Blinding patients is in such a way that explanations about the study are given and consent is given, but they are unaware of the type of prescription drug. The clinical caregiver and researcher is a person who is unaware of the type of prescription drug (is blind). While caring for the patient, the nurse and resident are unaware of the type of drug (blind). Only the drug code is mentioned in the form. Finally, the researcher enters the patient's file, based on the drug code, enters the type of drug in each patient's form.

Comparison of the effect of Apotel and Magnesium Sulfate on pain and dose of Pethidine in patients with maxillofacial surgery

6 months after publication of thesis

Oral and Maxillofacial Surgeons, Plastic Surgeons and ENT Surgeons

The data is fully available to individuals to perform the desired analysis

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