Comparative study of the effect of Anaheal and oral Corticosteroids in reducing Edema and Ecchymosis after Rhinoplasty.

Comparison of the effect of Anaheal and oral corticosteroids in reducing edema and ecchymosis after rhinoplasty

A randomized, blinded, clinical trial with tow parallel group design of 120 patient.

this study is performed in the offices and clinics of kermanshah dental school. 120 rhinoplasty applicants were randomly divided into two groups. In one group, Anaheal 500 is given daily, and in the second group, oral corticosteroids are given daily. the degree of ecchymosis and edema is calculated on a 4-point scale on the third, fifth, seventh days after surgery. the data is then analyzed. blinding is done with exactly the same drug packages that have secret codes related to the drug. patients and the executor of the project go blind

Inclusion criteria: All clients requesting rhinoplasty surgery exclusion criteria: Underlying diseases Taking oral or injectable drugs from other medical centers History of allergy to corticosteroid

In almost all patient with Rhinoplasty, edema and ecchymosis are seen as two expected outcomes of rhinoplasty. ecchymosis after surgery can be mild or severe, which depends on several factors, including the type and method of surgery and the patient's tendency to bruise. Postoperative edema is caused by an increase in interstitial fluid at the sit and can caused pain and, is severe, affect the final outcome of the surgery. Steroids reduce the permeability of the arteries and prevent exudate and blood from leaving the arteries. In this way, it prevents edema and ecchymosis. Anaheal is a combination of pineapple stem- derived protease enzymes that is used as an antiedema and antithrombotic and fibrinolytic properties.

primary consequence: The rate of edema and ecchymosis secondary consequence: does not have

The samples studied in this study will be done using random assignment of patient to the study groups. In the study, samples are assigned to the two groups by permutation block random sampling. Thus, the study will continue until the number of samples is completed. In the method, we first determine a sample size of the general sample and then randomly assign a set of them to one group and the rest to another group. to the perform this randomization method, we proceed as follow: 1- The total sample size and the sample size ratio in the groups are determined. in the study, the number of samples will be 120 people with a 1:1 allocation. 2- The number of samples will be selected from the table of random numbers of single-digit numbers between 0 and 9. 3- For studies with two groups, the numbers 0-9 are divided into two equal blocks with a probability of assigning an individual to each block of 0.5. block 0-4 can be used for the first group and block 5-9 for the second treatment. 4- Based on the selected numbers from the table of random numbers and determination of blocks, it is clear in which group each person who enters the study will be placed

Patients are treated with medication packages pre-determined by the study supervisor. drug packages are a quite similar in shape and patients are not aware of the contents of the packages. The cards with the number 1 and 2 on them and the secret codes related to the drug are in the packages and every patient who enters the study and receives the medicine dies not know the type of medicine. In addition, collecting information, assessing patients and completing forms is done by the project manager and his assistant, who are not aware of the contents of the packages; Therefore, the study is double-blind and the contents of the two drug groups are not clear from the stage of the patient entering the study until the end of the study.