A comparison of Succinylcholine and Rocuronium effects on the rate of emergence agitation when awakening in patients undergoing direct diagnostic laryngoscopy under general anesthesia

Determining the difference, severity and duration of agitation and the incidence of myalgia in patients undergoing rapid induction with Succinylcholine in general anesthesia compared with Rocuronium

Forty-eight patients aged 20 to 50 years with a risk of ASA1-2 anesthesia will be randomly divided into two groups: succinylcholine and rocuronium. After surgery, the degree of agitation when waking up in both groups was recorded according to RIKER criteria. The results will be analyzed using SPSS software.

48 patients aged 20 to 50 years with risk of ASA1-2 anesthesia who will refer to Rasoul Akram Hospital for direct diagnostic laryngoscopic surgery and will be subjected to endotracheal intubation in two groups by rapid sequencing method. The first group for premedication Will receive 3 μg/kg fentanyl and 0.5 mg / kg lidocaine and will be induced with 1 mg/kg succinylcholine and 5 mg/kg Nesdonal. The second group for premedication will receive 3 μg/kg of fentanyl and 0.5 mg/kg of lidocaine and will be induced with 0.6 mg / kg rocuronium and 5 mg/kg Nesdonal. In the second group, patients receive rocuronium instead of succinylcholine.

- Patients aged 20 to 50 years at risk of ASA1-2 anesthesia will be referred for diagnostic laryngoscopy surgery. - Patients with a history of burns, peritonitis, hyperkalemia, renal and hepatic insufficiency, malignant hyperthermia, pseudocholinesterase deficiency, addiction, a history of benzodiazepines, and a history of psychiatric illness will not be included in the study.

Patients are divided into two intervention groups receiving Succinylcholine and Rocuronium.

emergence agitation;Myalgia

Randomization in this clinical trial will be performed by blocking method. Accordingly, 8 blocks will be used, with 6 patients in each block (3 patients in the Saxinylcholine group and 3 patients in the Rocronium group). Randomization is done using random allocation softwares. In addition to simple randomization, these softwares are able to generate random sequences by blocking method. Random allocation concealment is used for hiding Which refers to the method used to execute a random sequence on the participants in the study, so that the assigned group is not known before the individual is assigned. Sequentially numbered opaque envelopes are also used, in which each of the random sequences created is recorded on a card and the cards are placed in the envelopes respectively. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the letter envelope lids are glued and placed in a box, respectively. At the beginning of the registration of participants, based on the order of entry of eligible participants into the study, one of the envelopes of the letter is opened in order and the assigned group of the participant is revealed.

Patient information will be recorded in the data collection sheets by examination by a physician. The patient, the injector, and the person recording the results will be unaware of the type of drug. The person preparing the medicine will be different from the person who injected it.

All data can be shared after people are not identified.

The data will be available 6 months after the results are published.

Researchers from scientific and academic institutions can apply for the data.

The data can only be used for scientific research by researchers in scientific and academic centers.

Researchers can send their request via email to the project manager.

Applications must be accompanied by a letter of introduction from the institution or university where the researcher is employed. The data will be provided to the researcher no later than two weeks after receiving the request.