Comparison of the effect of nonsteroidal anti-inflammatory drugs and acetaminophen on postpartum hypertension in patients with preeclampsia

Comparison of the effect of non-steroidal anti-inflammatory drugs and acetaminophen on postpartum hypertension in patients with preeclampsia, comparison of the time interval between delivery and the last blood pressure equal to and more than 110.160 mm Hg, comparison of mean mean arterial hypertension in postpartum patients To preeclampsia, compare the frequency of need for short-acting antihypertensive drugs to control sudden hypertension in patients with preeclampsia receiving nonsteroidal anti-inflammatory drugs and acetaminophen

Clinical trial with control group, with parallel groups, double-blinded, randomized, phase 2 on 110 patients. Excel software rand function was used for randomization.

Obstetrics and Gynecology; Ayatollah Taleghani Hospital in Arak; According to the criteria of the American Society of Obstetrics and Gynecology Surgery, they are included in the study with one of two diagnoses of severe preeclampsia or preeclampsia added to chronic hypertension with severe symptoms.

Inclusion criteria: Cesarean section candidates, age 18 to 35 years, no chronic liver-kidney disease and bleeding disorders, insensitivity to nonsteroidal anti-inflammatory drugs or acetaminophen; Exclusion criteria: increase in liver enzyme levels above 200 mg/dL, increase in serum creatinine levels above 2 mg/dL

Diclofenac group: 24 hours after delivery, administration of 50 mg diclofenac suppository every 8 hours until the end of hospitalization Acetaminophen group: 24 hours after delivery, administered of 325 mg of acetaminophen suppository every 6 hours until the end of hospitalization

Pregnancy blood pressure control; Postpartum blood pressure control; Less use of antihypertensive drugs during and after pregnancy

Random blocking with the size of random blocks (2, 4, 6) and randomization will be done using random sequence generation software, which in addition to simple randomization is able to generate random sequences by blocking method. We also use random allocation concealment, which is the method used to execute a random sequence on study participants so that the assigned group is not known before the individual is assigned. Using opaque envelopes sealed with random sequences, in this method, each of the random sequences created is recorded on a card and the cards are placed in the envelopes respectively. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the lids of the letter envelopes are glued and placed inside a box, respectively. At the beginning of the registration of participants, based on the order of entry of eligible participants into the study, one of the envelopes of the letter is opened and the assigned group of the participant is revealed.

Participants, principal investigator. The patient receives the drug (intervention or comparison group) in sealed packets that are coded. The coding is done by one of the project partners and the evaluator and the patient are blind.