-
Study aim
-
The aim of this study was to evaluate the effect of modified intermittent fasting regimen in comparison with energy constraints on anthropometric indices, glycemic markers, lipid parameters and hormone levels in people with polycystic ovary syndrome.
-
Design
-
The clinical randomized trial, sham- controlled clinical trial with parallel groups
-
Settings and conduct
-
Subjects were recruited from the Infertility Center. after classification and matched according to age and BMI, these subjects were randomly divided into two groups. a group of subjects received Modified ADF and another group received Calorie Restriction for 8 weeks. At the beginning and the end of the study, outcomes were measured. The energy requirement of each person was calculated by Mifflin equation.
-
Participants/Inclusion and exclusion criteria
-
Inclusion criteria: Women with polycystic ovary syndrome, Age between 25- 45, High BMI, No weight change more and less than 5% for 3 months, no fasting for 3 months, Absence of diseases such as diabetes, Do not take drugs that affect glycemic index and lipid parameters, No smoking and alcohol, Intense physical inactivity, Failure to follow specific diets,.
Exclusion criteria: Lack of cooperation of participants.
-
Intervention groups
-
For 2 weeks, the normal diet of individuals in both groups is observed and followed. In modified ADF group, subjects consumed very low- calorie diet (75% energy restriction) during the 3 fast days (Saturday, Monday, Wednesday) and then ate the diet that providing 125% of their energy needs on each feed day (3 days a week). In Friday subjects consumed ad libitum without limitation. In Calorie Restriction group, subjects consumed 75% energy needs in each day.
-
Main outcome variables
-
Weight, BMI, Waist circumference, Blood pressure, Fasting blood sugar, Total cholesterol, HDL, LDL, TG, FM, FFM, Fasting insulin, Prolactin, Testosterone, HOMA-IR, FSH, LH, TSH