The comparison of the effect of ondansetron and amisulpride on post operative nausea and vomiting (PONV) in general abdominal surgeries

Comparison of ondansetron and amisulpride effectiveness on post operative nausea and vomting (PONV) reduction in elective abdominal surgeries with general anesthesia.

In this randomized double-blind clinical trial, 116 patients who meet the inclusion criteria will be randomized using randomized numbers table in two groups and the intervention and bias in patient selection will be minimized by the researcher.

The subjects will be selected from patients undergoing elective surgeries with general anesthesia in Azad University hospitals during 2020 and 2021. Then, the patients will be divided into two groups which are matched in terms of age, gender and type of surgery. In the first group, at half an hour before the ondansetron surgery, 4 mg and in the other group at the same time, amisulpride is injected intravenously.

Indication for general anesthesia Being in ASA 1,2 anesthesia class Patient satisfaction to participate in the study Possibility of follow-up within 24 hours of abdominal surgery 18.5<BMI<30 Advanced underlying disease Patient dissatisfaction to participate in the study Catching Motion sickness Excessive bleeding during surgery Severe postoperative complications

The patients were divided into two groups that will be matched in terms of age, gender, type of surgery and type and method of general anesthesia. The first group will be injected intravenously with 4 mg of ondansetron within half an hour before the end of surgery and the other group will be injected 5 mg amisulpride intravenously. All patients will be evaluated for postoperative nausea and vomiting within 24 hours.

Ondansetron Amisulpride Gender Age BMI Post operative nausea and vomiting Stress Opioid

Using random numbers table

After confirmation of this study by the university's research committee, patients who are candidates for elective abdominal surgery with general anesthesia are introduced to the researcher by the professor of anesthesia. On the night before surgery, in order to meet the inclusion criteria and brief description of the study for the patient to be informed of the patient and get written consent of attachment number two on the patient's bedside will be present. It is also explained to the individual that their absence in this study does not cause any problems in the routine process of their treatment and is completely optional. It is also explained to them that according to appendix 1 questionnaire, 24 hours after surgery, they will be revisited to fill out the questionnaire. Patients who meet the inclusion criteria based on the criteria will be randomized using random numbers table in two groups and control will be minimized by this method of involvement and bias in patient selection by the researcher. Patients themselves do not have the right to choose to be in the case or control group. In order to blind the study on the day of surgery, the operating room personnel are unaware of the type of injectable drug and at the time of injection, syringes of the same shape and color will be provided to the anesthetic technician who does not know the content of the syringes. Finally, after collecting data and analyzing the data, the results are compared between the two groups.