Aims:
1-to compare fever ocurrance in the first 24 hour after suregry in both groups.
2- to compare amountof rise in body temperature in the first 24 hour after surgery in both groups.
Method: In this randomized, double-blind, placebo-controlled clinical, 80 children, aged 1-12years old, presenting for open heart surgery, were entered the trial and randomly allocated in to two groups: Placebo and Paracetamol. After induction of anaesthesia, 15mg/kg intravenous Paracetamol solution was infused during 1 hour in the Paracetamol group. Patients in placebo group received 15mg/kg normal saline infusion during the same time. Since the end of operation until next 24 hours in Intensive Care Unit, axillary temperature of the two group patients was recorded in four- hour intervals. Any fever occurred during this period, had been treated with Paracetamol suppository (125 mg) and the amount of antipyretic drug consumption for each patient had been recorded. In order to examine the safety of paracetamol, patients were evaluated for drug complication at the same time.
Variables: primary outcome variables were fever ocurrance and mean body temperature rise in the first 24 hour after surgery. secondary outcome variables were drug side efeects and amount of extra antipyretic agent used.
inclusion criteria: 1-12 year old children candidate for open heart surgery
exclusion criteria: previous sensitivity to paracetamol, liver disease, renal disease