The comparison sedation effect of intranasal ketamine and midazolam in premedication of child herniorrhaphy surgery

Determining the difference in sedation effect of midazolam and intranasal ketamine in preoperative pediatric hernioraf surgery at Bouali Hospital in Sari in 1399-1400

Random Allocation Clinical Trial with Parallel, Double-Blind, Randomized Phase 3 Groups on 36 Patients Random Allocation is used for randomization

Children one to six years old undergoing herniorafi surgery in Buali Hospital, Sari. The method of administration is midazolam (0.5 mg / kg) or ketamine (5 mg / kg)The researcher, who has no information about the type of drug, is given intranasally to the child half an hour before the procedure in the pre-treatment room, due to the double-blindness.

Inclusion criteria: - Age 1 to 6 years, physical condition according to the American Society of Anesthesia 1 or 2 (ASA PA), having informed consent of parents to participate in the study, patients who have a negative history of taking sedatives or analgesics in the past 24 hours, Patients with normal liver enzymes. , Patients who are normal in terms of psychological diseases, have food and drug allergies. Exclusion criteria: Allergy to any of the drugs used in premedication or during surgery, having any hemodynamic disorders, those with respiratory problems during surgery and airway disease The upper extremities are irritated like a cold. , Parental dissatisfaction.

Group of midazolam (0.5 mg / kg) intranasal and other group of ketamine (5 mg / kg) intranasal

Degree of children's relaxation, behavioral assessment, their heart rate, ease of separation from parents and their satisfaction

The random assignment process is blockade and the Random Allocation software used to block 6 blocks of 6 has been created. Both drugs are colorless and the nurse in charge of preparing the drugs in syringes A and B fills in the anesthesia assistant according to the randomization block. Random letters A and B are injected into the child without knowing the type of medicine, and also the person who performs sedation and analgesia and evaluates the child's behavior is completely unaware of the type of medicine. Then the person doing the sedation and pain assessment and assessing the child's behavior was also completely unaware of the type of medication.

For bilateral blindness, patients are divided into two groups of 18 people. Half an hour before the procedure, one group of midazolam (0.5 mg / kg) intranasal and the other group of ketamine (5 mg / kg) intranasal in the syringe without the name of the drug is prescribed. Becomes. The degree of sedation, behavioral assessment, heart rate, ease of separation from parents and their satisfaction are reviewed and recorded.