Comparison of the effects of preventive injection of 4 mg and 8 mg Ondansetron doses on pain caused by Etomidate injection in patients under general anesthesia

Comparison of the effect of preventive injection of 4 mg and 8 mg Ondansetron on pain caused by Etomidate injection

Clinical trial with control group, with parallel groups, double-blind, randomized, phase 3 on 60 patients. Lottery and sealed envelopes are used for randomization.

This is a randomized double-blind clinical trial that will be performed on 60 patients undergoing general anesthesia with Etomidate at Al-Zahra Hospital in Isfahan; After University Ethics Committee approval and patient satisfaction, patients were randomly assigned to the groups. In each group, the desired intervention is applied and the patient's clinical symptoms are recorded. The person who is performing the intervention would be different from the evaluator and they do not know the type of intervention. In spite of the fact that Patients are aware of the study, they are not aware of the type of intervention so they are all blind.

Inclusion criteria: ASA class I and II, age 18 to 60 years, general anesthesia candidate with Etomidate and patient informed consent to participate in the study Exclusion criteria: heart disease, psycho logic disease and diabetes, allergic to drugs used, addiction

Intervention group A: They receive 4 mg Ondansetron 2 minutes before inducing anesthesia Intervention group B: They receive 8 mg Ondansetron 2 minutes before inducing anesthesia Control group C: They receive 4 ml distilled water 2 minutes before inducing anesthesia, then all three groups will be induced under anesthesia with 20 mg Etomidate, and their clinical signs will be recorded.

Pain caused by Etomidate

This is a simple randomized clinical trial in which patients are entered the study groups by lottery; The medicines and placebo are placed in the sealed, opaque and similar form packets which are coded. Each code is also written on a piece of paper, folded, and placed inside a box. After entering the operating room, each patient takes one of the papers out of the box; The pocket with the same number is the intervention that will apply for him. This process continues till the number of patients will reach the desired one.

This is a double-blind clinical trial; In this way, before obtaining consent, patients are studied but do not know which group they will be in and therefore are blind. Also, the nurse who injects the drug and the researcher who records the patient's symptoms do not know the type of drug and are blind.