Protocol summary

Study aim
Evaluating the efficacy of low level laser therapy in decreasing the injection pain and post treatment pain in primary teeth
Design
Randomized clinical trial, split mouth, with crossover groups, triple blinded, over 30 patients, randomization achieved by SNOSE method.
Settings and conduct
In children within age of 6 to 9 year old visiting pediatric section of shahid beheshti dental school, requiring pulpotomy treatment in both E teeth of the maxilla and anesthesia with infiltration technique, in first session, a saline cotton is used to the site of injection and then low level laser is radiated to the site and the injection is performed. In the next session, a cotton smeared with topical anesthesia gel is used on the site of injection, and then the laser device is pointed to the site while the power is off, and then the injection is performed. At the end of each injection, the severity of pain is assessed by the Visual Analogue Scale.
Participants/Inclusion and exclusion criteria
Inclusion criteria: Need of pulpotomy treatment for both upper jaw E teeth requiring infiltration injection No history of bad dental treatment Children within age of 6 to 9 year old Exclusion criteria: Systemic disease Allergy to anesthesia drug Inflammation in the site of injection No consent of parents to participate in the study
Intervention groups
First Intervention group: radiation of low level laser therapy on tooth E of the maxilla on one side of a patient Second Intervention group: use of topical anesthesia gel on tooth E of the maxilla on the other side of the same patient
Main outcome variables
Severity of pain during injection Severity of pain after the removal of anesthesia after 1 hour and 24 hours of the treatment

General information

Reason for update
Acronym
LLLT
IRCT registration information
IRCT registration number: IRCT20210914052474N1
Registration date: 2021-11-04, 1400/08/13
Registration timing: prospective

Last update: 2021-11-04, 1400/08/13
Update count: 0
Registration date
2021-11-04, 1400/08/13
Registrant information
Name
Fatemeh Shekarchi
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 21 2217 5350
Email address
f.shekarchi@sbmu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2021-11-22, 1400/09/01
Expected recruitment end date
2022-01-05, 1400/10/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluating the efficacy of low level laser therapy in decreasing the injection pain and post treatment pain in primary teeth
Public title
Evaluating the efficacy of low level laser therapy in decreasing the injection pain and post treatment pain in primary teeth
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
Need of pulpotomy treatment in bilateral first primary molar teeth of upper jaw requiring infiltration anesthesia No record of bad dental treatment in the past Children within age of 6 to 9 year old
Exclusion criteria:
Systemic disease Allergy to local anesthesia drug Inflammation in the site of injection No consent of the parents to participate in the study
Age
From 6 years old to 9 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Participant
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 30
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Triple blinded
Blinding description
Patient is blinded by putting shield glasses on his/her eyes and thus he/she is unaware about the activation of the laser device. Result assessor is unaware about which method is used in the session and will only enters the pain score and so on he/she is blinded. The data is given to the analyzer by certain codes and he analyzes only the codes without knowing about their nature.
Placebo
Used
Assignment
Crossover
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Research institute of dental sciences- Shahid Beheshti university of medical sciences
Street address
No. 4, Moqadam close, South Ramin St, East Ferdows Blvd
City
Tehran
Province
Tehran
Postal code
1481999586
Approval date
2021-03-01, 1399/12/11
Ethics committee reference number
IR.SBMU.DRC.REC.1399.150

Health conditions studied

1

Description of health condition studied
Low level laser therapy in primary teeth
ICD-10 code
ICD-10 code description

Primary outcomes

1

Description
Severity of pain during injection
Timepoint
During injection
Method of measurement
Visual Analogue Scale

2

Description
Severity of pain after removal of anesthesia
Timepoint
1 hour and 24 hours after removal of anesthesia
Method of measurement
Visual Analogue Scale

Secondary outcomes

empty

Intervention groups

1

Description
First Intervention group: Low level laser therapy
Category
Treatment - Devices

2

Description
Second Intervention group: Topical anesthesia gel
Category
Treatment - Drugs

Recruitment centers

1

Recruitment center
Name of recruitment center
Shahid Beheshti dental school
Full name of responsible person
Fatemeh Shekarchi
Street address
Shahid Beheshti dental school, Daneshjoo Blvd, Velenjak
City
Tehran
Province
Tehran
Postal code
1983969411
Phone
+98 21 2217 5351
Email
fshekarchi92@gmail.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Afshin Zarghi
Street address
Shahid Beheshti Dental School, Daneshjoo Blvd, Velenjak
City
Tehran
Province
Tehran
Postal code
1983963113
Phone
+98 21 2203 2387
Email
Zarghi@sbmu.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Shahid Beheshti University of Medical Sciences
Proportion provided by this source
70
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Fatemeh Shekarchi
Position
Associate professor
Latest degree
Specialist
Other areas of specialty/work
Dentistry
Street address
Shahid Beheshti Dental school, Daneshjoo Blvd, Velenjak
City
Tehran
Province
Tehran
Postal code
1983969411
Phone
+98 21 2217 5351
Email
fshekarchi92@gmail.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Fatemeh Shekarchi
Position
Associate professor
Latest degree
Specialist
Other areas of specialty/work
Dentistry
Street address
Shahid Beheshti Dental school, Daneshjoo Blvd. Velenjak
City
Tehran
Province
Tehran
Postal code
1983969411
Phone
+98 21 2217 5351
Email
fshekarchi92@gmail.com

Person responsible for updating data

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Fatemeh Shekarchi
Position
Associate professor
Latest degree
Specialist
Other areas of specialty/work
Dentistry
Street address
Shahid Beheshti dental school, Daneshjoo Blvd, Velenjak
City
Tehran
Province
Tehran
Postal code
1983969411
Phone
+98 21 2217 5351
Email
fshekarchi92@gmail.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Yes - There is a plan to make this available
Data Dictionary
Yes - There is a plan to make this available
Title and more details about the data/document
The recorded data can be shared based on the studied indicators after identifying the sample individuals. These data include the numbers and scores reported from the Wong Baker FACES pain rating scale, and numbers recorded from the finger pulse oximeter at specified times, as well as results of statistical analysis of these data.
When the data will become available and for how long
e.g., starting 6 months after publication
To whom data/document is available
Researchers working in academic and scientific institutes can apply for access to the data.
Under which criteria data/document could be used
Performing statistical analyzes to compare data with other studies in this field is one of the conditions for access to data, so the analysis must be appropriate to the type of data received from the applicant.
From where data/document is obtainable
Applicants can obtain access to the data by submitting a request to the following email addresses in due time: soroush.amn@yahoo.com fshekarchi92@gmail.com
What processes are involved for a request to access data/document
After submitting the request by email, the applicant will be able to access the information within one week after submitting the request, if he/she has the requisite conditions.
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