Comparison the effect of acupressure and massage with ice on Hugo’s point on pain and Physiological parameters related to chemotherapy drug injection in children with acute lymphoblastic leukemia, clinical trial

Determining and comparing the effect of acupressure and Hugo point massage with ice on pain intensity and physiological parameters induced by chemotherapy injection in children with acute lymphoblastic leukemia

The clinical trial has two experimental and control groups, crossover, single blind, randomized, phase 1 on 52 patients. Four random blocks are used for randomization.

This study is performed in the blood and cancer ward of the Shahrivar Children's Educational and Medical Center in Rasht. In phase one, acupressure and ice massage interventions are performed in two groups, A and B. After one month and in the second phase, the intervention is transferred to two groups. In order to blind and prevent the effect of subjectivity on the research results, the interventions are performed by the main researcher and the consequences are measured by the researcher.

The study population was children 3-12 years old with acute lymphoblastic leukemia and treated with vincristine chemotherapy. Reluctance to cooperate and allergic response to chemotherapy are exclusion criteria.

In phase one in the experimental group, the point of the hand Hugo where the injection is not performed, for one minute with a piece of ice (diameter 2 cm) wrapped in plastic gloves and a single layer of cotton cloth, with the fingertips, in the form of Rotate in a clockwise direction with an average pressure of 3 to 4 kg, so that the maximum pressure time of one minute and then 10 seconds of pressure is cut off and generally lasts for 5 minutes. In the acupressure group, only pressure is applied to the point.After one month of these interventions and in the second phase, the intervention will be transferred to two groups.

Intensity of pain, Percentage arterial blood oxygen saturation, heart rate (pulse)

Four random blocks will be used for random assignment of samples to two groups of ice massage at Hugo point (group A) and acupressure (group B). The number of blocks required in this study is 13 blocks, based on which random allocation will be done. The sequence of random assignment of samples to two groups of ice massage at Hugo point (group A) and acupressure (group B) is determined through Random allocation online software. The sequence list of samples A and B will be kept in a sealed envelope in the nursing office of 17 Shahrivar Hospital in Rasht. After starting the study, it will be opened by the main researcher and based on gradual referrals, children in one of groups A or B Will be located and will continue until the estimated sample size in each group is reached.

In order to blind the researcher and prevent the effect of mentality on the research results, acupressure and ice massage at Hugo point will be done by one of the members of the research team (main researcher) and the measurement of pain and physiological indicators will be done by the researcher.