The effect of aerobic training and DASH diet on insulin resistance and sex hormones in women with polycystic ovary syndrome

Determining the effect of aerobic exercise and DASH diet on insulin and Resistance to insulin and sex hormones in women with polycystic ovary syndrome

A randomized controlled clinical trial on 60 patients who used a random number table for randomization.

60 women aged 20 to 40 years with polycystic ovary syndrome who are invited to participate in the study by a voluntary sports club.

1- Having at least two of the three criteria: a) low ovulation or no ovulation (which usually appears as algomenorrhea, amenorrhea, polymenorrhea) b) increase in circulating androgens, hirsutism and ratio LH / FSH> 2 and c) polycystic ovaries (seen on ultrasonography) 2- Being healthy based on health questionnaire 3- Do not take medicine 2- Not being older than 40 years and less than 20 years 3- No bmi less than ..... 4- Not having more bmi than ..... 5- Do not smoke 8- Do not suffer from muscle weakness related to known disorders such as stroke, cancer and cardiovascular diseases 9 - Do not use hormones and supplements as treatment 10 - Not participating in regular sports activities for at least the past year 12- Not having a separate diet outside the research program 14- Having a certificate from a doctor to perform sports exercises without hindrance

Aerobic exercise (running) for 12 weeks and 3 sessions per week for 25-30 minutes and an intensity of 60-85% of maximum heart rate is observed in accordance with the principle of extra load in the gym. DASH diet pattern: DASH diet was used for 8 weeks and the DASH diet consisted of 52% carbohydrates, 18% protein, 30, is full fat. This diet includes a high proportion of fruits and vegetables and a minimum of fat and sugar. The recommended amount of sodium in this diet is less than 2400 mg per day.

Resistance to insulin and sex hormones

60 participants are randomly divided into 4 groups using a table of random numbers. In the present study, the restricted randomization method was used, which will be performed in a block randomization method.The size of four blocks is equal and we will have four groups of 60 blocks (including 15 people participating in each group). Randomization tool also uses software random allocation software (Random allocation software). In addition to simple randomization, these random sequence generation software are able to generate random sequences by block generation method.For concealment, we use concealment allocation, so that the assigned group is not known before the individual is assigned.Using opaque envelopes sealed with random sequences (envelopes opaque, sealed, numbered sequentially), in which each random sequence is recorded on a card. And the cards are placed in the envelopes of the letter, respectively.In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface.Finally, the lids of the letter envelopes are glued and placed inside a box, respectively. At the beginning of the registration of participants, based on the order of entry of eligible participants into the study, one of the envelopes of the letter is opened in order and the assigned group of the participant is revealed.