Comparison of therapeutic effects of topical ketorolac versus topical diclofenac in the treatment of knee osteoarthritis pain: a clinical trial

Making Ketorolac Cream and Comparing the Therapeutic Effects of Topical Diclofenac Ketorolac in Relieving Knee Osteoarthritis Pain

randomized, parallel‐group, double‐blind, placebo‐controlled phase 2 clinical trial on 60 patients (two groups of 30).

Shahid Sadoughi Hospital, Yazd, The effect of ketorolac in comparison with diclofenac on osteoarthritis of the knee, double-blind clinical trial (orthopedic physician and patient, none of the grouping will be known. The patient will be randomly divided into 2 groups receiving topical ketorolac, or topical diclofenac randomly divided into permutation blocks (30 in each group). And 3 times a day, they use its topical form for 2 weeks. Patients did not use other therapies such as exercise and physiotherapy during the 2 weeks of the study and will not change their treatment regimen during this period.

Patients over 40 years of age with primary tibiofemoral or patellofemoral osteoarthritis with baseline WOMAC scale

Control group: topical diclofenac 1% three times a day for two weeks Intervention group: topical ketorolac three times a day for two weeks If the pain is not controlled with each of the topical products, the patient can use acetaminophen tablets in the form of 500 mg up to 4 grams per day. The number of tablets is recorded by the patient and recorded in the visits by the student.

Joint range of motion, swelling rate, amount and severity of pain, joint dryness

Patients were randomly assigned to two groups of 20 controls or interventions by the permutation block method. Ten blocks of 4 are considered. Generation of random codes using Permuted Block Randomization method will be done with the help of Random allocation software (version 1). The first person who is eligible to enter the study is given number one and likewise, the last eligible person is given number 40. By using the software-generated table, patients receive each intervention A or B (Each of the letters A and B will be installed on similar containers of the interventions). In order to consider blinding in random allocation, the list is given to another person outside the study and using short message service (SMS) before assigning the type of treatment according to the number of eligible people is asked and thus people enter the study.

After the products have been prepared, the first Executor, the treating physician, and the researcher monitoring the patients will not be aware of any of the groupings performed. In this way, after preparing the products, which all look the same, are placed in similar boxes. Then we ask another person to identify them with the codes A or B.