The effect of single oral dose vitamin D on left ventricular remodelling in patients with acute anterior left ventricular infarction referred to Shahid Rajaei Hospital and comparison with randomized clinical trial control group IRCTcular

The effect of oral dose of vitamin D bolus on left ventricular remodeling in patients with acute anterior left ventricular infarction referred to Rajaei Hospital

A block randomized, phase 3, double-blind mode

144 patients are divided into two groups based on a random number (block) table. The intervention group, in addition to standard treatment, receives a dose of 50,000 units of calciferol, and the control group receives only standard treatment. Upon the arrival of all patients, the vitamin d calcium and troponin checks are echoed shortly afterward and the criteria are assessed. The troponin is checked daily and the level below the troponin chart is calculated and the patient echo is repeated two months later. Then the information is entered into SPSS and the two groups are compared. It should be noted that the study is double-blind

Inclusion criteria: aged 40-85 years; diagnosis of anterior infarction less than 12 hours after the onset of symptoms; patient informed consent. Exclusion criteria: history of infarction, history of abnormal LV EF; cardiomyopathy, Vitamin D supplementation, Moderate to severe valvular disease, Calcium above 10.5, allergy to vitamin D supplementation, People with BMI >30, Life-threatening medical conditions include renal or liver failure, cancer, and rheumatic and immunological diseases.

Patients with acute anterior left ventricular infarction who are referred to Rajai Hospital in Karaj will receive vitamin D if they receive <30 doses of 50,000 units of vitamin D bolus. The control group is people with deficiencies who do not receive vitamin D.

sphericity index / LV EDDI/LV ESVI/LV EDVI//LV EF / LVESDI/ LV mass/ GLS Troponin /diastolic disfunction

Randomization will be performed by block randomization method with heterogeneous blocks 2, 4, and 6 to hide the allocation order. The randomization list will be prepared in advance using the software available on the relevant, reputable website. (https://www.sealedenvelope.com/simple-randomiser/v1/lists). After the physician (responsible researcher) determines that the patient is eligible, the researcher, who has the confidential randomization list, will be contacted to assign the patient to one of the two groups.

Both the data analyzer and the sample collector are kept blind. These people do not know which study group the questionnaire they fill out with patients belongs to. Intervention or control. Analysts also analyze raw information in which it is not clear whether this information is for the control group or the intervention.