Inclusion criteria: HD treatment at least twice a week for a maximum of 4 hours each time, HD treatment for at least 6 months before, no pregnancy or lactation, no immune deficiency, no history of active cancers, no history of disease Severe chronic and acute medical conditions such as lung disease, cardiovascular disease, liver and acute pancreatitis, non-addiction and consumption of alcohol or drugs, lack of severe digestive disorders and diseases, HIV disease, mental health problems, ability to drink at least 200 ml of water Day, life expectancy and survival for at least 3 months and confirmation of written consent.
Exclusion criteria: Patients with severe edema, people who had an infection 4 weeks ago, people who used synbiotics, probiotics, prebiotics or antibiotics during the 4 weeks before the study, people who are candidates for kidney and organ transplants or Peritoneal dialysis during 3 months of study, taking immunosuppressive drugs or anticoagulants and chemotherapy drugs, sensitivity to complementary components, patient's unwillingness to participate in the study, failure to fully answer questions or report side effects from use synbiotics.