A study on effects of ischemic preconditioning on the occurrence rate of major cardiovascular complications in patients suffering from acute myocardial infraction with ST segment elevation

Determining the effect of Remote Ischemic Preconditioning(RIC) on the incidence of cardiovascular major complications in patients with acute myocardial infarction with ST-segment elevation(STEMI)

Study of single-blind randomized clinical trial with STEMI patients and Primary percutaneous coronary intervention candidates in both intervention and control groups 80 patients in the intervention group and 80 patients in the control group based on consecutive sampling and having inclusion criteria based on four random blocks whose sequence by Sealed Envelope software block randomization specified, will be reviewed.

Patients who are referred to the emergency department of Heshmat Hospital due to STEMI. Patients in the intervention group, before PCI, undergo Ischemic Preconditioning Remote in such a way that their upper limbs are subjected to ischemia 3 times with a pressure cuff of 30 mmHg above systolic pressure and each time for 5 minutes They are stretched and then emptied for 5 minutes. However, in the control group, only the pressure gauge cuff is closed. Finally, the information obtained is recorded in a checklist.

Inclusion criteria: Patients over 18 years of age with chest pain and onset of pain less than 12 hours and ECG with ST-elevation equal or higher than0.1mv in two leads together Exclusion criteria: cardiogenic shock. dying before or immediately after . past myocardial infarction or vascular bypass surgery. 12 hours or more have elapsed since the onset of maximal chest pain.

Patients referred due to STEMI are included in the study and the RIC procedure is performed on patients in the case group.

LVEF; stroke; Myocardial reinfarction; New heart failure; Death

According to the estimated sample size, 80 patients in the intervention group and 80 patients in the control group based on consecutive sampling and having inclusion criteria based on four random blocks whose sequence by Sealed Envelope software Ltd.2021.Created a block Randomisation list {Online} Available from: https://www.sealedenvelope.com/simple -randomiser / v1 / lists {Accessed 13 Sep 2021} The list is kept inside a sealed letter at the Healthy Heart Research Center. After permission to conduct the study, patients are assigned to the intervention and control groups on a daily basis. It should be noted that this sequence list consists of 40 quadruple random blocks. This study is a single-blind clinical trial study. The method of blinding in the study will be that the intervention of patients by one of the assistants and the evaluation of complications and measurement of left ventricular ejection fraction by another assistant. Patients have no information about the type of intervention.

This study is a single-blind clinical trial. the independent variable in this study is the intervention group against control group, the outcomes of this study(heart failure, recurring myocardial infraction, stroke and death) are the primary end points , and ejection fraction(EF) is the secondary end point.

All data is potentially shareable after unidentified individuals.

Access period 6 months after printing the results

Researchers working in academic and scientific institutions

In order to conduct further research at the written request of the Scientific Institute.

applicants for receiving documents and data can refer to the Healthy Heart Research Center located in Heshmat Hospital. They can also call 01333664282.

The applicant can refer to the Healthy Heart Research Center after receiving Confirmation from the project manager, the documents and data will be available to him within a week.