Objective: This study is to determine the effects of garlic on metabolic profiles, hs-CRP and biomarkers of oxidative stress in pregnant women at risk for pre-eclampsia. Study design: Randomized double-blind controlled clinical trial. Inclusion and Exclusion Criteria: Pregnant women, primigravida, aged 18-40 year old at 27 weeks' gestation with positive roll-over test will be included in this study. Multiparous women as well as those with hypertension, gestational diabetes mellitus (GDM), complete bed rest (CBR), intra uterine fetal death (IUFD), placenta abruption and preterm delivery will be excluded in the study. Population and sample size: 60 pregnant women of eligible and referred to Kossar Clinic affiliated to Arak University of Medical Sciences, Arak, Iran in the study will be selected. Intervention: Patients will be assigned to receive either 400 mg garlic (intervention group: n=30) or placebo (control group: n=30). Fasting blood samples will be taken at baseline and after 9-wk intervention to measure metabolic profiles and biomarkers of oxidative stress. Start and End Date of Intervention: 9 weeks (November 28, 2013- January 7, 2014). Outcomes: Baseline and End-of-trial serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides levels, fasting plasma glucose (FPG), plasma total antioxidant capacity (TAC) and total glutathione (GSH).