Comparison of the analgesic effect of lidocaine, pethidine and their composition in Bier Block anesthesia in patients with distal radius fracture

The aim of this study is to evaluate the analgesic effect of lidocaine, pethidine and the combined of both in the Beirblock method in patients with distal radius fractures referred to the orthopedic operating room of Shahid Bahonar Hospital in Kerman in 2022.

Clinical trial has 3 groups, with factorial groups (Control group: lidocaine (3mg/kg) Intervention group1: pethidine (0/6mg/kg) Intervention group2: both lidocaine (3mg/kg) and pethidine (0/6mg/kg) ) ,double-blind, randomized, phase 2 on 90 patients. Using random numbers a third party will assign them to three groups.

Location: Operating room of Bahonar Hospital in Kerman Double-blind. Before starting the patient's VAS will be measured.Drugs will be injected intravenously then a tourniquet will be placed on the arm of the operated hand. Cuff pressure will 150 mm Hg above systolic pressure, A minimum of 250 mm Hg will be adjusted. The disappearing of the radial pulse will confirm sufficient tourniquet pressure. Then the complications of CNS and heart and the amount of sensory and motor block will be evaluated.Due to the colorlessness of the drugs, the patient will be blind. Only the anesthesiologist will be aware of the type of medication, and therefore the assessing physician will be unaware of the analgesic treatment protocol.

Inclusion criteria: distal radius fracture and age between 18 to 65 years Exclusion criteria: Allergy to local anesthetics, heart, Kidney ,Lung ,Brain disease Diabetes, Allergy to pethidine and other drugs and Drug users

Control group: lidocaine (3mg/kg) group1: pethidine (0/6mg/kg) group2: both lidocaine (3mg/kg) and pethidine (0/6mg/kg)

Pain sensation is assessed based on VAS. The degree of sensation of touch will be scored from zero to two (no sense: zero, vague sense: 1 and full sense: 2)

In this study, patients were randomly divided into 3 groups of 30 using a sequence of random numbers made by SAS statistical software. Based on this method, a random list of numbers is made and the assignment of patients to groups is determined based on the order of their entry. Sealed, opaque numbered envelopes were used to hide randomization

This study is performed in a double-blind manner. The drugs will be injected intravenously. Due to the colorlessness of the drugs, the patient will be blind. Only the anesthesiologist will be aware of the type of medication, and therefore the researcher and the assessing physician will be unaware of the analgesic treatment protocol.

At the end of the study, some of the information, including the effect of prescribing her, pethidine , lidocaine and the combination of both on the bier block anesthesia on distal radius fractures surgery, it will share with health workers.

2 months after data analysis

Health researchers

In order to use the results and during the written request

Mansour Mortezazadeh Meimand-Email

The purpose of accessing data - requesting e-mail-After a week