Comparison of the effect of intravenous injection of meperidin with dexamethasone and midazolam onpostoperative shivering in patients recovering from general anaesthesia in post orthopedic surgery

Comparison of the effect of intravenous injection of meperidin with dexamethasone and midazolam onpostoperative shivering in patients recovering from general anaesthesia in post orthopedic surgery

Three arm parallel group randomized trial with 40 patients in each group, randomized with block randomization method Block randomization method is used for allocation .

This study will be performed in Madani hospital, Karj on all participants with orthopedic surgeries under general anesthesia eligible for the study. Patients who have consciously signed a consent form to participate in the project will be randomly assigned to three groups. The randomization list will be prepared by the statistician. Treatments will be placed in sealed envelopes and will be kept by the out-of-study nurse. After identification of the eligibility of the patient, the procedure will be explained to her and informed consent will be obtained, completing the final information is the responsibility of the person who is unaware of the type of treatment. The statistician will also be blind.

Inclusion criteria: Patients undergoing elective orthopedic surgery , at least 8 hours of fasting ,ages between 18 and 65 years ,ASA class 1,2 Exclusion criteria: Having hypothermia or hyperthermia

Intervention group 1: participants will received meperidine at a dose of 0.4 mg per kg. Goup2: participants will received dexamethasone at a dose of 0.15 mg per kg Intervention group3: participants will received midazolam at a dose of 0.05 mg per kg

Shivering after surgery with general anesthesia

Our sample size is 120people, with 40 people in each group. Block randomization method was designed by epidemiologist using STATA version 13 software. The number of blocks considered is 6

The random allocation list will solely available to the epidemiologist. 120 cards containing sequences of treatments will be written and be placed inside sealed envelopes. A10-digit random code, as the patient’s identification number, will be provided for each packet. When the physician announces the eligibility of a patient, the nurse will provide the physician with the envelope. None of the patients should be aware of the type and process of treatment. Also, the person evaluating the outcomes is a third person who is unaware of the random allocation process and type of treatment. Data analysis will be carried out by a statistician who is aware of all the processes performed.