Comparison of the effectiveness of aripiprazole and risperidone on the psychotic symptoms of methamphetamine use

Comparing effectiveness of aripiprazole and risperidone in methamphetamine induced psychosis

A block Randomized using a block size of 4, double blinded, two arm parallel group, clinical trial wich is performed on 32 patients in each experimental group.

eligible patients Admitted in razi psychiatric hospital diagnosed with Metamphetamin induced psychosis, would be assessed by researcher made questionnaire, vital signs and positive and negative syndrome scale after informed consent and before medication.assessment will be repeated using vital signs and positive and negative syndrome scale 1 week after medication. assessments are going to be repeated again using positive and negative syndrome scale and vital signs and saint Hans rating scale 4weeks after medication. researcher and data gatherer and patients would be unaware of the medication type and physical features of two medication types are going to be similar.

inclusion criteria: informed consent to enter the trial, No other substance dependencies except for Tobacco, diagnosis of Metamphetamin induced psychotic disorder based on Diagnostic and Statistical Manual of Mental Disorders 5th Edition exclusion criteria: major or urgent psychiatric or nonpsychiatric condition including allergies to Risperidone or Aripiprazole, Psychiatric medication use in last 4 weeks other than Benzodiazepines

intervention group 1:taking Risperidone oral tablet, 2-8mg over 24 hours variable dosage decided by clinical care giver, daily, for at least a month and Abidi pharma brand; intervention group 2:taking Aripiprazole oral tablet, 5-20mg over 24 hours variable dosage decided by clinical care giver, daily, for at least a month and Abidi pharma brand

Score of positive and negative syndrom scale

We are going to divide samples into two (A) and (B) groups using block randomization of size 4. letters A and B would be used randomly to make 6 blocks of 4 letters and 6 blocks are going to be labeled with numbers 1 to 6. 16 times, random numbers from 1 to 6 are chosen and corresponding block of letters are written down in a row. For example if the first random number is 2 and second number is 5, letters in block no.2 are written down and letters in block no.5 are going to be written after (repeated up to 16 blocks) and a random row of letters A and B ( of size 64) is generated. Number for Place of letters in the row would be written on the sealed envelope and the letters would be placed inside. The envelopes with numbers coresponding to the number of the patients according to participation time, is opened by researcher and group of each participant is determined (A or B) when they roll into the study.

this is a double blinded study. Both participants and researcher who is tasked with diagnosis and clinical evaluation, are unaware of the medication given to participants. shape, smell, color and taste of both medications are similar which are delivered by a nurse and researcher is invited by clinical care giver to perform the evaluation.