Comparison of four drugs clonidine, bisoprolol, tranexamic acid and gabapentin on bleeding rate, hemodynamic stability and intraoperative surgeon satisfaction in patients undergoing rhinoplasty surgery.

Comparison of four drugs clonidine, bisoprolol, tranexamic acid and gabapentin on bleeding rate, hemodynamic stability and intraoperative surgeon satisfaction

This study will be a double-blind randomized clinical trial with parallel groups on 75 patients referred to Motahhari Hospital in Jahrom who undergo rhinoplasty surgery. In this study, computerized block randomization (13 blocks of 10) will be performed. An independent epidemiologist who is not involved in the study will use a random blockchain program (SATA14) to generate allocation codes. Random sequences will be placed in light-resistant and sealed envelopes. The research assistant will open sealed, numbered, and opaque envelopes containing the assignment codes.

Patients referred to Motahari Hospital in Jahrom who will undergo rhinoplasty surgery will be included in the study. Patients participating in the study will be divided into five groups by throwing dice: clonidine, bisoprolol, gabapentin, tranexamic acid and control. The person participating in the study, the researcher and the data collector will be unaware of the type of drug used.

Inclusion criteria: All patients referred to Motahhari Hospital in Jahrom who underwent rhinoplasty and expressed their consent to participate in the study. Exclusion criteria : includes patients who do not have hemodynamic stability.

Intervention group 1: They will receive clonidine / 2 mg intravenously. Intervention group 2: They will receive 5.2 mg bisoprolol tablets. Intervention group 3:They will receive 4 capsules gabapentin 300 mg . The intervention group 4:They will receive 4 capsules of 250 mg tranexamic acid. Intervention group 5: They will receive a placebo as a control group.

Bleeding, hemodynamic stability and surgical surgeon satisfaction

In this study, computerized block randomization (13 blocks of 10) will be performed. An independent epidemiologist who is not involved in the study will use a random blockchain program (SATA 14) to generate allocation codes. Eligible participants, after signing the informed consent form, will be divided into five equal groups: clonidine, bisoprolol, gabapentin, tranexamic acid and placebo. Random sequences will be placed in light-resistant and sealed envelopes. The research assistant will open sealed, numbered, and opaque envelopes containing the assignment codes.

For blinding in the present study, the double-blind method is used, so that 1- the person who reviews the results and 2- the person who performs the injections do not know which patient has received clonidine, bisoprolol, gabapentin, tranxamic acid and Placebo only.The drugs Clonidine, bisoprolol, gabapentin, tranexamic acid, and placebo will be packaged in identical glass( two groups of clonidine and bisoprolol, which are in the form of tablets, are powdered and then placed in capsules. The capsules will be the same in all 5 groups) and given to the prescriber, and will be placed in the drug or placebo group, according to a random list, and the glass will be marked A, B, C, D, E will be given to the patient and the patient will be unaware of the type of medicine used.