The effect of eight weeks of combined training (resistance-aerobic) and propolis supplementation on serum levels of adipolin (CTRP12) and secretory protein associated with secretory curvature (SFRP5) and Interleukin-6 (IL-6) and glycemic indexes in women with type 2 diabetes with dyslipidemia

Evaluation of a course of combined training and consumption of propolis supplement on serum level of adipolin and inflammatory factor and glycemic indexes in type 2 diabetic women with dyslipidemia

This study was a randomized, placebo-controlled, clinical trial with parallel and double-blind groups on 40 participants using available sampling method. Randomization is performed by a person who does not participate in the study. The researcher numbers the subjects' names and puts the numbers in an envelope, and another person enters the names, and the participants enter the intervention or placebo groups.

The statistical population of this study is type 2 diabetic women in Shiraz. 40 of these people are selected based on the inclusion and exclusion criteria of the study and after completing the consent form, randomly and blindly divided into 4 groups (exercise + propolis supplement, exercise + Placebo, supplement group and placebo group) are divided. None of the subjects will be aware of the status of supplementation and groupings.

Inclusion criteria, female sex and fasting glucose of subjects equal to or greater than 126 mg / dL, triglyceride greater than 150 mg / dL; The criterion for not entering, any skin or gastrointestinal allergies to propolis and is to have any underlying disease.

Combined exercise includes 20 minutes of aerobic exercise and 45 minutes of resistance training, 3-4 sessions per week + propolis supplement (3 propolis tablets at a dose of 300 mg), combined exercise + placebo (3 placebo tablets with the same protocol as the intervention group), supplement group and A group of placebos are divided. The study participants did not know that their pills contained a Propolis supplement or a placebo.

serum levels of adipolin and SFRP5 and Interleukin-6

The statistical population of this study is women 40 to 60 years old with type 2 diabetes in Shiraz who will be selected by clinical trial. According to the corona conditions, the sample size is estimated to be 40 people and then the subjects are divided into 4 groups using simple random sampling, which are: The first group: propolis supplement (10 people). The second group: propolis supplement and exercise (10 people); The third group: placebo (10 people), the fourth group: exercise and placebo (10 people) will be divided. None of the subjects will be aware of the status of supplements and groupings. The researcher numbers the names of the subjects and puts the numbers in the envelope, and another person enters the names and puts them in 4 groups, respectively.

All study participants (subjects) are aware that propolis supplementation is to be considered in this study, but are not aware of the contents of the capsule (placebo or propolis) they are taking. The main researchers of the research (student, supervisor and consultant professor) will not be informed which capsule (placebo or propolis) which subject is consuming until the end of the research. Laboratory personnel who are responsible for sampling and measuring variables are also unaware of which subjects are taking which capsules (placebo or supplement). Patients in the supplement and exercise + supplement group take 3 tablets with 300 mg of propolis for eight weeks three times a day one hour after each meal. The placebo and placebo + exercise groups receive the same amount of placebo. The placebo and propolis supplement are placed inside the capsule in exactly the same way.

All data is potentially shareable after unidentified individuals.

The start of the data access period is 6 months after the publication of the articles.

The data will only be available to researchers working at academic institutions.

The data will be generally available and unpublishable by the recipient.

To receive research information, send an email to fatemeh_m8040@yahoo.com

After obtaining permission from the project manager, the data will be sent.